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En metode til at studere sammenhængen mellem lokal kollagenstruktur og mekaniske egenskaber af aterosklerotisk plaque-fibrøst væv
JoVE Journal
Bioingegneria
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JoVE Journal Bioingegneria
A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

En metode til at studere sammenhængen mellem lokal kollagenstruktur og mekaniske egenskaber af aterosklerotisk plaque-fibrøst væv

DOI:
10.3791/64334-v

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13:45 min

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November 11, 2022

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, , , , , , ,
1Department of Biomedical Engineering,Erasmus Medical Center, 2Department of Biomedical Engineering,Eindhoven University of Technology, 3Department of Biomechanical Engineering,Delft University of Technology, 4Erasmus Optical Imaging Center,Erasmus Medical Center

Capitoli

  • 00:05Introduction
  • 00:46Tissue Sample Preparation and Multiphoton Microscopy (MPM) Imaging
  • 06:04Mechanical Testing
  • 07:55Data Analysis
  • 11:22Results: Studying Heterogeneous Structural and Mechanical Atherosclerotic Plaque Properties
  • 13:06Conclusion

Summary

Traduzione automatica

Traduzione automatica

Vi har udviklet en mekano-billeddannelse pipeline til at studere de heterogene strukturelle og mekaniske aterosklerotiske plaque egenskaber. Denne rørledning muliggør korrelation af den lokale fremherskende vinkel og spredning af kollagenfiberorientering, brudadfærden og belastningsfingeraftrykkene af det fibrøse plakvæv.

Tags

Keywords: Collagen StructureMechanical PropertiesAtherosclerotic PlaquePlaque RuptureTensile TestingMicroscopyTile Scan

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