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一种研究动脉粥样硬化斑块纤维组织局部胶原结构与力学性能相关性的方法
JoVE Journal
Bioingegneria
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JoVE Journal Bioingegneria
A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
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一种研究动脉粥样硬化斑块纤维组织局部胶原结构与力学性能相关性的方法

DOI:
10.3791/64334-v

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13:45 min

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November 11, 2022

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, , , , , , ,
1Department of Biomedical Engineering,Erasmus Medical Center, 2Department of Biomedical Engineering,Eindhoven University of Technology, 3Department of Biomechanical Engineering,Delft University of Technology, 4Erasmus Optical Imaging Center,Erasmus Medical Center

Capitoli

  • 00:05Introduction
  • 00:46Tissue Sample Preparation and Multiphoton Microscopy (MPM) Imaging
  • 06:04Mechanical Testing
  • 07:55Data Analysis
  • 11:22Results: Studying Heterogeneous Structural and Mechanical Atherosclerotic Plaque Properties
  • 13:06Conclusion

Summary

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我们开发了一种机械成像管道来研究异质结构和机械动脉粥样硬化斑块特性。该管道能够关联胶原纤维取向的局部优势角度和分散、破裂行为和纤维斑块组织的应变指纹。

Tags

Keywords: Collagen StructureMechanical PropertiesAtherosclerotic PlaquePlaque RuptureTensile TestingMicroscopyTile Scan

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