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使用转录组学分析绘制无序致癌转录因子的结构-功能关系
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June 27, 2020
DOI:
1Center for Childhood Cancer and Blood Diseases,Abigail Wexner Research Institute at Nationwide Children’s Hospital, 2Molecular, Cellular, and Developmental Biology Program,The Ohio State University, 3Division of Pediatric Hematology/Oncology/Blood & Marrow Transplant,The Ohio State University, 4Department of Pediatrics,The Ohio State University
Summary
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内在无序结构域对致癌融合转录因子功能很重要。为了治疗靶向这些蛋白质，需要更详细地了解这些结构域所采用的调节机制。在这里，我们使用转录组学来绘制尤文氏肉瘤中内在无序的EWS结构域的重要结构特征。
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Cite this Article
Showpnil, I. A., Miller, K. R., Taslim, C., Pishas, K. I., Lessnick, S. L., Theisen, E. R. Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis. J. Vis. Exp. (160), e61564, doi:10.3791/61564 (2020).
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