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An In Vivo Assessment of Blood-Brain Barrier Disruption in a Rat Model of Ischemic Stroke
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JoVE Journal Neuroscienze
An In Vivo Assessment of Blood-Brain Barrier Disruption in a Rat Model of Ischemic Stroke

An In Vivo Assessment of Blood-Brain Barrier Disruption in a Rat Model of Ischemic Stroke

DOI:
10.3791/57156-v

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12:19 min

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March 11, 2018

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, , ,
1Department of Physiology, Medical School,Ardabil University of Medical Sciences, 2Neurosciences Research Center,Tabriz University of Medical Sciences, 3Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy,Tabriz University of Medical Sciences

Capitoli

  • 00:00Titolo
  • 01:19Anesthesia and flowmetery
  • 03:08Induction of the focal cerebral ischemia
  • 05:50Jugular vein cannulation and Evans blue (EB) injection
  • 08:12Assessment of the blood-brain barrier (BBB) permeability
  • 10:09Representative Results
  • 11:15Conclusion

Summary

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The overall goal of this procedure is to provide a highly reproducible technique for in vivo assessment of the blood-brain barrier disruption in rat models of ischemic stroke.

Tags

Keywords: Blood-brain BarrierIschemic StrokeRat ModelMiddle Cerebral Artery OcclusionEvans Blue DyeAnesthesiaCerebral Blood FlowFocal Cerebral IschemiaCommon Carotid Artery

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