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干粉和药品的雾化吸入气雾剂递送小鼠使用鼻只曝光系统

JoVE Journal
Medicina

This content is Free Access.

JoVE Journal Medicina

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

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干粉和药品的雾化吸入气雾剂递送小鼠使用鼻只曝光系统

39,929 Views

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07:28 min

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April 06, 2017

DOI:

10.3791/55454-v

DOI:

10.3791/55454-v

•

07:28 min

April 06, 2017

•

16 Views

Jonathan E. Phillips¹, Xuxia Zhang¹, James A. Johnston¹

¹Inflammation Research,Amgen

Summary

本文所描述的吸入单元可以产生，样品表征和在啮齿类动物的肺中均匀地沉积的药物气雾剂。这使得临床前确定的有效性和沉积于肺部药物剂量的安全性的;关键数据，使临床吸入药物的发展。

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