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Immunology and Infection

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JoVE Journal Immunology and Infection
A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
 

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries

Article DOI: 10.3791/54829-v • 09:39 min • December 27th, 2016
December 27th, 2016 •
1, 1, 1
1Pharmaceutical Design and Discovery (PharmDD), Faculty of Pharmacy, University of Helsinki

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Biofilm infections show high tolerance towards chemotherapy. No single assay captures the complexity of biofilms. Instead, complementary assays are needed. We present a screening platform (developed for S. aureus) that combines assays for viability, biomass, and biofilm matrix. It allows anti-biofilm drug discovery, including the assessment of long-term chemotherapeutic effects.

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Anti-biofilm Assays Natural Compound Libraries Screening Workflow Viability Biomass Biofilm Matrix Antibiofilm Agent Discovery Chemotherapeutic Effects Chemical Libraries Natural Compounds Bacterial Culture Antibiotic Stock Solution Incubate Cultures Resazurin Staining Multichannel Pipette Sterile PBS
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