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קדימה גנטיקה מסכי שימוש המקרופאגים לזיהוי<em> Toxoplasma gondii</emחסינות אוטונומית נייד להתנגדות לIFN-γ-Dependent> גנים חשובים
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Immunologia e infezioni
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JoVE Journal Immunologia e infezioni
Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity
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קדימה גנטיקה מסכי שימוש המקרופאגים לזיהוי<em> Toxoplasma gondii</emחסינות אוטונומית נייד להתנגדות לIFN-γ-Dependent> גנים חשובים

10,923 Views

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11:21 min

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March 12, 2015

DOI:

10.3791/52556-v

DOI:
10.3791/52556-v

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11:21 min
March 12, 2015

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2 Views
, , , , , , ,
1Department of Microbiology and Immunology,New York Medical College

Summary

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Forward genetics is a powerful approach to identify genes in intracellular pathogens important for resistance to cell autonomous immunity. The current approach uses innate immune cells, specifically macrophages, to identify novel Toxoplasma gondii genes important for immune evasion.

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Cite this Article

Walwyn, O., Skariah, S., Lynch, B., Kim, N., Ueda, Y., Vohora, N., Choe, J., Mordue, D. G. Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity. J. Vis. Exp. (97), e52556, doi:10.3791/52556 (2015).

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