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A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors

JoVE Journal
Neuroscienze

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JoVE Journal Neuroscienze

A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors

A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors

8,497 Views

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14:10 min

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November 14, 2014

DOI:

10.3791/51915-v

DOI:

10.3791/51915-v

•

14:10 min

November 14, 2014

•

2 Views

Krishna P. Kota⁶, Veronica Soloveva^6,7, Laura M. Wanner⁶, Glenn Gomba⁶, Erkan Kiris^5,6, Rekha G. Panchal, Christopher D. Kane^6,7, Sina Bavari

¹Perkin Elmer Inc., ²Henry M. Jackson Foundation, ³The Geneva Foundation, ⁴ORISE, ⁵Frederick National Laboratory for Cancer Research, ⁶Division of Molecular and Translational Sciences,US Army Medical Research Institute of Infectious Diseases, ⁷DoD Biotechnology High Performance Computing Software Applications Institute (BHSAI), Telemedicine and Advanced Technology Research Center (TATRC),US Army Medical Research and Materiel Command (USAMRMC)

Tags

High Content Imaging Botulinum Neurotoxin Inhibitors SNAP-25 SNARE Complex BoNT/A Motor Neurons High-throughput Screening Small Molecule Libraries Immunostaining Image Acquisition Image Analysis

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