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Неинвазивная изображений и анализ церебральной ишемии в живых крысах с использованием позитронно-эмиссионной томографии с<sup> 18</sup> F-ФДГ
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December 28, 2014
DOI:
1W. M. Keck Center for Transgene Research,University of Notre Dame, 2Department of Chemistry and Biochemistry,University of Notre Dame, 3Notre Dame Integrated Imaging Facility,University of Notre Dame, 4Department of Biological Sciences,University of Notre Dame, 5Harper Cancer Research Institute,University of Notre Dame
Summary
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Brain damage resulting from cerebral ischemia may be non-invasively imaged and studied in rats using pre-clinical positron emission tomography coupled with the injectable radioactive probe, 18F-fluorodeoxyglucose. Further, the use of modern software tools that include volume of interest (VOI) brain templates dramatically increase the quantitative information gleaned from these studies.
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Balsara, R. D., Chapman, S. E., Sander, I. M., Donahue, D. L., Liepert, L., Castellino, F. J., Leevy, W. M. Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG. J. Vis. Exp. (94), e51495, doi:10.3791/51495 (2014).
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