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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Capitoli
- 00:05Titolo
- 01:24Tail Immersion Test (TIT)
- 02:39Tail Pressure Test (TPT)
- 03:31Acute Morphine-induced Analgesia
- 04:42Chronic Morphine Treatment
- 05:32Results: Morphine-induced Hyperalgesia and Analgesic Tolerance
- 06:48Conclusion
We describe a protocol to examine the development of opioid-induced hyperalgesia and tolerance in mice. Based on the measurement of thermal and mechanical nociceptive responses of naïve and morphine-treated animals, it allows to quantify the increase in pain sensitivity (hyperalgesia) and decrease in analgesia (tolerance) associated with chronic opiate administration.
