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Granulocyt-afhankelijke auto-antilichaam-geïnduceerde blaarvorming
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Immunologia e infezioni
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JoVE Journal Immunologia e infezioni
Granulocyte-dependent Autoantibody-induced Skin Blistering
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Granulocyt-afhankelijke auto-antilichaam-geïnduceerde blaarvorming

10,384 Views

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12:23 min

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October 12, 2012

DOI:

10.3791/4250-v

DOI:
10.3791/4250-v

•

12:23 min
October 12, 2012

•

4 Views
, ,
1Department of Dermatology,University of Freiburg , 2Kepler High School Freiburg, 3Centre for Biological Signalling Studies (BIOSS),University of Freiburg

Summary

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In het diermodel beschreven in onze huidige werk gezuiverde IgG antilichamen tegen een stuk van 200 aminozuren (aa 757-967) van collageen VII herhaaldelijk geïnjecteerd in muizen reproduceren blaarvorming fenotype en de histo-en immunopathologische kenmerken vertonen de menselijke epidermolysis bullosa acquisita (EBA)<sup> 1</sup>.

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Cite this Article

Csorba, K., Sitaru, S., Sitaru, C. Granulocyte-dependent Autoantibody-induced Skin Blistering. J. Vis. Exp. (68), e4250, doi:10.3791/4250 (2012).

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