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Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding
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Capitoli
- 00:00Titolo
- 01:07Introduction
- 01:57R2 HIV-1 Strain V3 Loop ab initio Folding via the ICM-Pro GUI
- 04:19R2 HIV-1 Strain V3 Loop ab initio Folding via the ICM-Pro Command Line
- 06:35 ab initio Folding Data Analysis
- 08:41Representative Results for R2 HIV-1 Strain V3 Loop ab initio Folding
- 09:59Conclusion
The crown region of different V3 loop sequences of the surface envelope glycoprotein (gp120) of HIV-1 can be structurally characterized in many cases by in silico folding of positions 10 to 22 of the loop using a state-of-the-art ab initio folding algorithm. Here we demonstrate the folding and evaluation of this region of the V3 loop from the R2 strain of HIV-1, a uniquely neutralization sensitive strain with puzzling functional properties.
