State University of New York College of Nanoscale Science and Engineering (SUNY CNSE) 1 article published in JoVE Medicine Vascular Balloon Injury and Intraluminal Administration in Rat Carotid Artery Wei Zhang1, Mohamed Trebak1 1Nanobioscience, State University of New York College of Nanoscale Science and Engineering (SUNY CNSE) This protocol uses a balloon catheter to cause an intraluminal injury on the rat carotid artery and henceforth elicit neointimal hyperplasia. This is a well-established model for studying the mechanisms of vascular remodeling in response to injury. It is also widely used to determine the validity of potential therapeutic approaches.