Combining Imaging and Electrophysiology to Visualize and Record Spreading Depolarizations in Mice

Brandi R. Hess; Devon S. Hatcher; Johann Pacheco; Myah K. McDonald; Natalie J. Pinkowski; Raycarlo Laboy-Ramirez; Z. Matthew Situ; Taha F. Abdeljawad; Carissa J. Mehos; Russell  A. Morton

doi:10.3791/67032

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Neuroscienze

Detecting Spreading Depolarization Using AC Amplifiers and Non-Invasive Imaging

October 04, 2024

Author Spotlight: Deciphering the Connection Between Spreading Depolarizations and Mild Traumatic Brain Injuries

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Brandi R. Hess*¹, Devon S. Hatcher*¹, Johann Pacheco¹, Myah K. McDonald¹, Natalie J. Pinkowski¹, Raycarlo Laboy-Ramirez¹, Z. Matthew Situ¹, Taha F. Abdeljawad¹, Carissa J. Mehos¹, Russell A. Morton¹

¹Department of Neurosciences and The Center for Brain Recovery and Repair,University of New Mexico School of Medicine

Summary

This protocol demonstrates the combination of imaging and electrophysiology to reliably detect spreading depolarizations in adult mice following a mild traumatic brain injury.

Detecting Spreading Depolarization Using AC Amplifiers and Non-Invasive Imaging

Author Spotlight: Deciphering the Connection Between Spreading Depolarizations and Mild Traumatic Brain Injuries

Summary

Article