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SFEMG in Rodents: Assessing NMJ Function in Health and Disease

SFEMG in Rodents: Assessing NMJ Function in Health and Disease

March 08, 2024

Author Spotlight: Translational Applications of Stimulated SFEMG in Rodent Models

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1NextGen Precision Health,University of Missouri, 2Department of Physical Medicine and Rehabilitation,University of Missouri, 3Department of Neurology,University of Missouri, 4Department of Medical Pharmacology and Physiology,University of Missouri

Summary

In this study, we demonstrate a refined single fiber electromyography (SFEMG) protocol to allow in vivo measurement of neuromuscular junction (NMJ) transmission in rodent models. A step-by-step approach to the SFEMG technique is described to allow quantification of NMJ transmission variability and failure in rat gastrocnemius muscle.

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