Maria S. Remedi Department of Medicine, Division of Endocrinology Washington University School of Medicine Biography Publications Institution JoVE Articles Maria S. Remedi has not added a biography. If you are Maria S. Remedi and would like to personalize this page please email our Author Liaison for assistance. Publications Intermittent Fasting Protects β-cell Identity and Function in a Type-2 Diabetes Model Metabolism: Clinical and Experimental. Apr, 2024 | Pubmed ID: 38307325 KATP Channels Are Necessary for Glucose-dependent Increases in Amyloid-β and Alzheimer's Disease-related Pathology JCI Insight. May, 2023 | Pubmed ID: 37129980 Glucokinase Inhibition: A Novel Treatment for Diabetes? Diabetes. Feb, 2023 | Pubmed ID: 36669001 A Unique High-Output Cardiac Hypertrophy Phenotype Arising From Low Systemic Vascular Resistance in Cantu Syndrome Journal of the American Heart Association. Dec, 2022 | Pubmed ID: 36515236 Genetic Reduction of Glucose Metabolism Preserves Functional β-Cell Mass in KATP-Induced Neonatal Diabetes Diabetes. Jun, 2022 | Pubmed ID: 35294000 ATP-Sensitive Potassium Channels in Hyperinsulinism and Type 2 Diabetes: Inconvenient Paradox or New Paradigm? Diabetes. Mar, 2022 | Pubmed ID: 35196393 Cognitive Deficits and Impaired Hippocampal Long-term Potentiation in K-induced DEND Syndrome Proceedings of the National Academy of Sciences of the United States of America. Nov, 2021 | Pubmed ID: 34732576 Gain-of-Function Lrp5 Mutation Improves Bone Mass and Strength and Delays Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jul, 2021 | Pubmed ID: 33831261 Complex Consequences of Cantu Syndrome SUR2 Variant R1154Q in Genetically Modified Mice JCI Insight. 03, 2021 | Pubmed ID: 33529173 Preferential Gq Signaling in Diabetes: an Electrical Switch in Incretin Action and in Diabetes Progression? The Journal of Clinical Investigation. Dec, 2020 | Pubmed ID: 33196460 Kir6.1- and SUR2-dependent KATP Overactivity Disrupts Intestinal Motility in Murine Models of Cantú Syndrome JCI Insight. Nov, 2020 | Pubmed ID: 33170808 The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in Cantú Syndrome Function (Oxford, England). 2020 | Pubmed ID: 32865539 Alterations in Pancreatic Islet Cell Function in Response to Small Bowel Resection American Journal of Physiology. Gastrointestinal and Liver Physiology. Jul, 2020 | Pubmed ID: 32463335 Kir6.1-dependent K Channels in Lymphatic Smooth Muscle and Vessel Dysfunction in Mice with Kir6.1 Gain-of-function The Journal of Physiology. May, 2020 | Pubmed ID: 32372450 Glibenclamide Reverses Cardiovascular Abnormalities of Cantu Syndrome Driven by KATP Channel Overactivity The Journal of Clinical Investigation. Mar, 2020 | Pubmed ID: 31821173 Cantú Syndrome: Findings from 74 Patients in the International Cantú Syndrome Registry American Journal of Medical Genetics. Part C, Seminars in Medical Genetics. Dec, 2019 | Pubmed ID: 31828977 ABCC9-related Intellectual Disability Myopathy Syndrome is a K Channelopathy with Loss-of-function Mutations in ABCC9 Nature Communications. Oct, 2019 | Pubmed ID: 31575858 The Role of Membrane Excitability in Pancreatic β-cell Glucotoxicity Scientific Reports. May, 2019 | Pubmed ID: 31061431 In Vivo Monitoring of Intracellular Ca Dynamics in the Pancreatic β-cells of Zebrafish Embryos Islets. 2018 | Pubmed ID: 30521410 Cardiovascular Consequences of KATP Overactivity in Cantu Syndrome JCI Insight. 08, 2018 | Pubmed ID: 30089727 High-fat-diet-induced Remission of Diabetes in a Subset of K -GOF Insulin-secretory-deficient Mice Diabetes, Obesity & Metabolism. Nov, 2018 | Pubmed ID: 29896801 Intermittent Fasting Preserves Beta-cell Mass in Obesity-induced Diabetes Via the Autophagy-lysosome Pathway Autophagy. 2017 | Pubmed ID: 28853981 Should I Stay or Should I Go: A Clash of α-Cell Identity Cell Metabolism. Mar, 2017 | Pubmed ID: 28273469 Diabetes Induced by Gain-of-function Mutations in the Kir6.1 Subunit of the KATP Channel The Journal of General Physiology. Jan, 2017 | Pubmed ID: 27956473 Rpl13a Small Nucleolar RNAs Regulate Systemic Glucose Metabolism The Journal of Clinical Investigation. Dec, 2016 | Pubmed ID: 27820699 An Ancestral Role for the Mitochondrial Pyruvate Carrier in Glucose-stimulated Insulin Secretion Molecular Metabolism. Aug, 2016 | Pubmed ID: 27656398 Pancreatic β-cell Identity in Diabetes Diabetes, Obesity & Metabolism. Sep, 2016 | Pubmed ID: 27615139 Remission of Severe Neonatal Diabetes with Very Early Sulfonylurea Treatment Diabetes Care. Mar, 2015 | Pubmed ID: 25715421 Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-stimulated Insulin Secretion Cell Reports. Jun, 2014 | Pubmed ID: 24910426 Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation Following Insulin Therapy Cell Metabolism. May, 2014 | Pubmed ID: 24746806 Hypotension Due to Kir6.1 Gain-of-function in Vascular Smooth Muscle Journal of the American Heart Association. Aug, 2013 | Pubmed ID: 23974906 Acute Sulfonylurea Therapy at Disease Onset Can Cause Permanent Remission of KATP-induced Diabetes Diabetes. Oct, 2011 | Pubmed ID: 21813803 HMR 1098 is Not an SUR Isotype Specific Inhibitor of Heterologous or Sarcolemmal K ATP Channels Journal of Molecular and Cellular Cardiology. Mar, 2011 | Pubmed ID: 21185839 K(ATP) Channelopathies in the Pancreas Pflugers Archiv : European Journal of Physiology. Jul, 2010 | Pubmed ID: 19921246 Hyperinsulinism and Diabetes: Genetic Dissection of Beta Cell Metabolism-excitation Coupling in Mice Cell Metabolism. Dec, 2009 | Pubmed ID: 19945402 Secondary Consequences of Beta Cell Inexcitability: Identification and Prevention in a Murine Model of K(ATP)-induced Neonatal Diabetes Mellitus Cell Metabolism. Feb, 2009 | Pubmed ID: 19187772 Ca2+-independent Alterations in Diastolic Sarcomere Length and Relaxation Kinetics in a Mouse Model of Lipotoxic Diabetic Cardiomyopathy Circulation Research. Jan, 2009 | Pubmed ID: 19023131 Chronic Antidiabetic Sulfonylureas in Vivo: Reversible Effects on Mouse Pancreatic Beta-cells PLoS Medicine. Oct, 2008 | Pubmed ID: 18959471 Expression of ATP-insensitive KATP Channels in Pancreatic Beta-cells Underlies a Spectrum of Diabetic Phenotypes Diabetes. Nov, 2006 | Pubmed ID: 17065331 Hyperinsulinism in Mice with Heterozygous Loss of K(ATP) Channels Diabetologia. Oct, 2006 | Pubmed ID: 16924481 Critical Role of Gap Junction Coupled KATP Channel Activity for Regulated Insulin Secretion PLoS Biology. Feb, 2006 | Pubmed ID: 16402858 Glucose-stimulated DNA Synthesis Through Mammalian Target of Rapamycin (mTOR) is Regulated by KATP Channels: Effects on Cell Cycle Progression in Rodent Islets The Journal of Biological Chemistry. Feb, 2006 | Pubmed ID: 16344552 ATP-sensitive K+ Channel Signaling in Glucokinase-deficient Diabetes Diabetes. Oct, 2005 | Pubmed ID: 16186394 ATP and Sulfonylurea Sensitivity of Mutant ATP-sensitive K+ Channels in Neonatal Diabetes: Implications for Pharmacogenomic Therapy Diabetes. Sep, 2005 | Pubmed ID: 16123353 Transgenic Overexpression of SUR1 in the Heart Suppresses Sarcolemmal K(ATP) Journal of Molecular and Cellular Cardiology. Oct, 2005 | Pubmed ID: 16099470 Diet-induced Glucose Intolerance in Mice with Decreased Beta-cell ATP-sensitive K+ Channels Diabetes. Dec, 2004 | Pubmed ID: 15561946 Signaling Elements Involved in the Metabolic Regulation of MTOR by Nutrients, Incretins, and Growth Factors in Islets Diabetes. Dec, 2004 | Pubmed ID: 15561916 Remodeling of Excitation-contraction Coupling in Transgenic Mice Expressing ATP-insensitive Sarcolemmal KATP Channels American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2004 | Pubmed ID: 14656703 HIV Protease Inhibitors Acutely Impair Glucose-stimulated Insulin Release Diabetes. Jul, 2003 | Pubmed ID: 12829635 Author Spotlight: Techniques and Challenges in Islet Purification for Xenotransplantation Sophia H. Roberts1,2, Louai Alrata1,2, Dahlia Abdulsattar1,2, Karan Joseph1,2, Wahid Abu-Amer1,2, Mohamed Zaghloul1,2, Batool Arif1,2, Tarek Alhamad3, Maria S. Remedi4, Yiing Lin5, Mohamed A. Zayed1,2,6,7 1Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, 2CardioVascular Research Innovation in Surgery and Engineering Center, Washington University School of Medicine, 3Department of Medicine, Division of Nephrology, Washington University School of Medicine, 4Department of Medicine, Division of Endocrinology, Washington University School of Medicine, 5Department of Surgery, Section of Transplant Surgery, Washington University School of Medicine, 6Division of Molecular Cell Biology, Washington University School of Medicine, 7Department of Biomedical Engineering, Washington University McKelvey School of Engineering JoVE 66350 Medicina
Author Spotlight: Techniques and Challenges in Islet Purification for Xenotransplantation Sophia H. Roberts1,2, Louai Alrata1,2, Dahlia Abdulsattar1,2, Karan Joseph1,2, Wahid Abu-Amer1,2, Mohamed Zaghloul1,2, Batool Arif1,2, Tarek Alhamad3, Maria S. Remedi4, Yiing Lin5, Mohamed A. Zayed1,2,6,7 1Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, 2CardioVascular Research Innovation in Surgery and Engineering Center, Washington University School of Medicine, 3Department of Medicine, Division of Nephrology, Washington University School of Medicine, 4Department of Medicine, Division of Endocrinology, Washington University School of Medicine, 5Department of Surgery, Section of Transplant Surgery, Washington University School of Medicine, 6Division of Molecular Cell Biology, Washington University School of Medicine, 7Department of Biomedical Engineering, Washington University McKelvey School of Engineering JoVE 66350 Medicina