Jianqing Xu Institutes of Biomedical Sciences Fudan University Biography Publications Institution JoVE Articles Jianqing Xu has not added a biography. If you are Jianqing Xu and would like to personalize this page please email our Author Liaison for assistance. Publications A Fusion Protein Approach to Integrate Antiviral and Anti-inflammatory Activities for Developing New Therapeutics Against Influenza A Virus Infection Antiviral Research. Jun, 2024 | Pubmed ID: 38862076 Efficacy and Safety of Novel Multifunctional M10 CAR-T Cells in HIV-1-infected Patients: a Phase I, Multicenter, Single-arm, Open-label Study Cell Discovery. May, 2024 | Pubmed ID: 38740803 Reduced Clinical Severity During 2022 Shanghai Spring Epidemic of SARS-CoV-2 Omicron BA.2 Variant Infection-an Integrated Account of Virus Pathogenicity and Vaccination Effectiveness National Science Review. Apr, 2024 | Pubmed ID: 38699632 Integrated Single-cell Transcriptome and T Cell Receptor Profiling Reveals Defects of T Cell Exhaustion in Pulmonary Tuberculosis The Journal of Infection. Jun, 2024 | Pubmed ID: 38642678 An Intranasal Combination Vaccine Induces Systemic and Mucosal Immunity Against COVID-19 and Influenza NPJ Vaccines. Mar, 2024 | Pubmed ID: 38509167 Integration of HiBiT into Enteroviruses: A Universal Tool for Advancing Enterovirus Virology Research Virologica Sinica. Mar, 2024 | Pubmed ID: 38499155 Construction of an Infectious Clone for Enterovirus A89 and Mutagenesis Analysis of Viral Infection and Cell Binding Microbiology Spectrum. Apr, 2024 | Pubmed ID: 38441464 PB2 Residue 473 Contributes to the Mammalian Virulence of H7N9 Avian Influenza Virus by Modulating Viral Polymerase Activity Via ANP32A Journal of Virology. Mar, 2024 | Pubmed ID: 38421166 BTLA Contributes to Acute-on-chronic Liver Failure Infection and Mortality Through CD4 T-cell Exhaustion Nature Communications. Feb, 2024 | Pubmed ID: 38418488 Asialoglycoprotein Receptor 1 Promotes SARS-CoV-2 Infection of Human Normal Hepatocytes Signal Transduction and Targeted Therapy. Feb, 2024 | Pubmed ID: 38355848 One HA Stalk Topping Multiple Heads As a Novel Influenza Vaccine Emerging Microbes & Infections. Dec, 2024 | Pubmed ID: 38044872 A Non-human Primate Derived Anti-P-selectin Glycoprotein Ligand-1 Antibody Curtails Acute Pancreatitis by Alleviating the Inflammatory Responses Acta Pharmaceutica Sinica. B. Nov, 2023 | Pubmed ID: 37969726 A Follow-up Study on the Recovery and Reinfection of Omicron COVID-19 Patients in Shanghai, China Emerging Microbes & Infections. Dec, 2023 | Pubmed ID: 37732336 Adhesion Portion FimH Polarizes M2 Macrophages to M1 Macrophages in Tumor Microenvironment Via Toll-like Receptor 4 Frontiers in Immunology. 2023 | Pubmed ID: 37720226 Broad-spectrum Vaccine Via Combined Immunization Routes Triggers Potent Immunity to SARS-CoV-2 and Its Variants Journal of Virology. Oct, 2023 | Pubmed ID: 37706688 CD160 Signaling Is Essential for CD8+ T Cell Memory Formation Via Upregulation of 4-1BB Journal of Immunology (Baltimore, Md. : 1950). Nov, 2023 | Pubmed ID: 37695685 Single-cell RNA-sequencing Reveals Heterogeneity and Intercellular Crosstalk in Human Tuberculosis Lung The Journal of Infection. Nov, 2023 | Pubmed ID: 37690670 Scopoletin Reactivates Latent HIV-1 by Inducing NF-κB Expression Without Global T Cell Activation International Journal of Molecular Sciences. Aug, 2023 | Pubmed ID: 37628826 Exosomal LncRNA LINC01268 Promotes Pancreatic Cancer Progression Via the MiR-217-KIF2A-PI3K/AKT Axis Genes & Diseases. Sep, 2023 | Pubmed ID: 37492701 Safety and Clinical Response to Combined Immunotherapy with Autologous INKT Cells and PD-1CD8 T Cells in Patients Failing First-line Chemotherapy in Stage IV Pancreatic Cancer Cancer Research Communications. Jun, 2023 | Pubmed ID: 37377605 A LY6E-PHB1-TRIM21 Assembly Degrades CD14 Protein to Mitigate LPS-induced Inflammatory Response IScience. Jun, 2023 | Pubmed ID: 37250795 Glutamylation of an HIV-1 Protein Inhibits the Immune Response by Hijacking STING Cell Reports. May, 2023 | Pubmed ID: 37099423 Induced Regulatory T Cells Modified by Knocking Down T-bet in Combination with Ectopic Expression of Inhibitory Cytokines Effectively Protect Graft-versus-host Disease American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Jul, 2023 | Pubmed ID: 37084847 Adipose-derived Stem Cells Show Hepatic Differentiation Potential and Therapeutic Effect in Rats with Acute Liver Failure Acta Biochimica Et Biophysica Sinica. Apr, 2023 | Pubmed ID: 37078751 Corrigendum: A Single Vaccination of Nucleoside-modified Rabies MRNA Vaccine Induces Prolonged Highly Protective Immune Responses in Mice Frontiers in Immunology. 2023 | Pubmed ID: 36776830 SARS-COV-2 Spike Protein Promotes RPE Cell Senescence Via the ROS/P53/P21 Pathway Biogerontology. Oct, 2023 | Pubmed ID: 36738354 Allogeneic Gene-edited HIV-specific CAR-T Cells Secreting PD-1 Blocking ScFv Enhance Specific Cytotoxic Activity Against HIV Env Cells Invivo Virologica Sinica. Apr, 2023 | Pubmed ID: 36657565 NamiRNA-enhancer Network of MiR-492 Activates the NR2C1-TGF-β/Smad3 Pathway to Promote Epithelial-mesenchymal Transition of Pancreatic Cancer Carcinogenesis. May, 2023 | Pubmed ID: 36591938 Nonmuscle Myosin IIA Promotes the Internalization of Influenza A Virus and Regulates Viral Polymerase Activity Through Interacting with Nucleoprotein in Human Pulmonary Cells Virologica Sinica. Feb, 2023 | Pubmed ID: 36509386 Rapid Generation of a Mouse Model for Evaluating On-target Normal Tissue Toxicity of Human CAR-T Cells Using Replication-defective Recombinant Adenovirus Journal of Advanced Research. May, 2023 | Pubmed ID: 35995414 The Arms Race in the War Between Virus and Host: Implications for Anti-Infection Immunity Infectious Diseases & Immunity. Jul, 2022 | Pubmed ID: 37520109 Innate Immune Response in Respiratory System: A Double-edged Sword Against Virus Infection Infectious Diseases & Immunity. Jul, 2022 | Pubmed ID: 37520107 A Single Vaccination of Nucleoside-modified Rabies MRNA Vaccine Induces Prolonged Highly Protective Immune Responses in Mice Frontiers in Immunology. 2022 | Pubmed ID: 36761167 The Development and Characterization of a Stable Coxsackievirus A16 Infectious Clone with Nanoluc Reporter Gene Frontiers in Microbiology. 2022 | Pubmed ID: 36704559 A Randomized, Double-blind, Placebo-controlled Phase I Trial of Inhalation Treatment of Recombinant TFF2-IFN Protein: A Multifunctional Candidate for the Treatment of COVID-19 Frontiers in Pharmacology. 2022 | Pubmed ID: 36578554 Improving the Expansion of Human Tumor-reactive CD8 + T Cells by Targeting Toll-like Receptors Frontiers in Bioengineering and Biotechnology. 2022 | Pubmed ID: 36394017 Neutralization of Five SARS-CoV-2 Variants of Concern by Convalescent and BBIBP-CorV Vaccinee Serum Virologica Sinica. Dec, 2022 | Pubmed ID: 36309305 FBXO34 Promotes Latent HIV-1 Activation by Post-transcriptional Modulation Emerging Microbes & Infections. Dec, 2022 | Pubmed ID: 36285453 Revealing the Characteristics of ZIKV Infection Through Tissue-specific Transcriptome Sequencing Analysis BMC Genomics. Oct, 2022 | Pubmed ID: 36209057 The Neutralization of B.1.617.1 and B.1.1.529 Sera from Convalescent Patients and BBIBP-CorV Vaccines IScience. Sep, 2022 | Pubmed ID: 36062074 Comparison of H7N9 and H9N2 Influenza Infections in Mouse Model Unravels the Importance of Early Innate Immune Response in Host Protection Frontiers in Cellular and Infection Microbiology. 2022 | Pubmed ID: 36034707 Shows Unique Patterns of Codon Usage Bias in Conventional Versus Unconventional Clade Frontiers in Cellular and Infection Microbiology. 2022 | Pubmed ID: 35909978 Angiotensin-Converting Enzyme 2 Potentiates SARS-CoV-2 Infection by Antagonizing Type I Interferon Induction and Its Down-Stream Signaling Pathway MSphere. Aug, 2022 | Pubmed ID: 35862802 Comprehensive RNA-seq Reveals Molecular Changes in Kidney Malignancy Among People Living with HIV Molecular Therapy. Nucleic Acids. Sep, 2022 | Pubmed ID: 35795483 Neutralization Mechanism of a Human Antibody with Pan-coronavirus Reactivity Including SARS-CoV-2 Nature Microbiology. Jul, 2022 | Pubmed ID: 35773398 Recombinant Programmed Cell Death Protein 1 Functions As an Immune Check Point Blockade and Enhances Anti-cancer Immunity Biomaterials. Jun, 2022 | Pubmed ID: 35533439 Pathologically Complete Remission to Combination of Invariant NK T Cells and Anti-CD20 Antibody in a Refractory HIV+ Diffuse Large B-cell Lymphoma Patient Immunotherapy. Jun, 2022 | Pubmed ID: 35443802 Feasibility of INKT Cell and PD-1+CD8+ T Cell-based Immunotherapy in Patients with Lung Adenocarcinoma: Preliminary Results of a Phase I/II Clinical Trial Clinical Immunology (Orlando, Fla.). May, 2022 | Pubmed ID: 35367396 Author Correction: Receptome Profiling Identifies KREMEN1 and ASGR1 As Alternative Functional Receptors of SARS-CoV-2 Cell Research. Jun, 2022 | Pubmed ID: 35365756 Hymecromone: a Clinical Prescription Hyaluronan Inhibitor for Efficiently Blocking COVID-19 Progression Signal Transduction and Targeted Therapy. Mar, 2022 | Pubmed ID: 35304437 Prompt Antiviral Action of Pulmonary CD8+ T Cells Is Mediated by Rapid IFN-γ Induction and Its Downstream ISGs in the Lung Frontiers in Immunology. 2022 | Pubmed ID: 35296070 SARS-CoV-2 RNA Elements Share Human Sequence Identity and Upregulate Hyaluronan Via NamiRNA-enhancer Network EBioMedicine. Feb, 2022 | Pubmed ID: 35124429 CoVac501, a Self-adjuvanting Peptide Vaccine Conjugated with TLR7 Agonists, Against SARS-CoV-2 Induces Protective Immunity Cell Discovery. Feb, 2022 | Pubmed ID: 35102138 Implications of the Accumulation of CXCR5 NK Cells in Lymph Nodes of HIV-1 Infected Patients EBioMedicine. Jan, 2022 | Pubmed ID: 34973625 The Kinase Complex MTORC2 Promotes the Longevity of Virus-specific Memory CD4 T Cells by Preventing Ferroptosis Nature Immunology. Feb, 2022 | Pubmed ID: 34949833 Receptome Profiling Identifies KREMEN1 and ASGR1 As Alternative Functional Receptors of SARS-CoV-2 Cell Research. Jan, 2022 | Pubmed ID: 34837059 HIV-1 Vif Suppresses Antiviral Immunity by Targeting STING Cellular & Molecular Immunology. 01, 2022 | Pubmed ID: 34811497 Boosting Vaccine-Elicited Respiratory Mucosal and Systemic COVID-19 Immunity in Mice With the Oral Frontiers in Nutrition. 2021 | Pubmed ID: 35004816 Nonmuscle Myosin Heavy Chain IIA Facilitates SARS-CoV-2 Infection in Human Pulmonary Cells Proceedings of the National Academy of Sciences of the United States of America. Dec, 2021 | Pubmed ID: 34873039 Hsa-miR-31 Governs T-Cell Homeostasis in HIV Protection IFN-γ-Stat1-T-Bet Axis Frontiers in Immunology. 2021 | Pubmed ID: 34804062 Influenza A Virus-Host Specificity: An Ongoing Cross-Talk Between Viral and Host Factors Frontiers in Microbiology. 2021 | Pubmed ID: 34803997 Development of Recombinant COVID-19 Vaccine Based on CHO-produced, Prefusion Spike Trimer and Alum/CpG Adjuvants Vaccine. Nov, 2021 | Pubmed ID: 34750014 Comprehensive Mapping of Binding Hot Spots of SARS-CoV-2 RBD-specific Neutralizing Antibodies for Tracking Immune Escape Variants Genome Medicine. Oct, 2021 | Pubmed ID: 34649620 Conditioned CAR-T Cells by Hypoxia-inducible Transcription Amplification (HiTA) System Significantly Enhances Systemic Safety and Retains Antitumor Efficacy Journal for Immunotherapy of Cancer. Oct, 2021 | Pubmed ID: 34615704 Expansion of Human INKT Cells Ex Vivo Methods in Molecular Biology (Clifton, N.J.). 2021 | Pubmed ID: 34524667 High Expression of CD38 and MHC Class II on CD8 T Cells During Severe Influenza Disease Reflects Bystander Activation and Trogocytosis Clinical & Translational Immunology. 2021 | Pubmed ID: 34522380 A Human Cell-based SARS-CoV-2 Vaccine Elicits Potent Neutralizing Antibody Responses and Protects Mice from SARS-CoV-2 Challenge Emerging Microbes & Infections. Dec, 2021 | Pubmed ID: 34304724 FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat MBio. Aug, 2021 | Pubmed ID: 34281390 Monitoring Coronavirus Disease 2019: A Review of Available Diagnostic Tools Frontiers in Public Health. 2021 | Pubmed ID: 34164371 Immune Cellular Networks Underlying Recovery from Influenza Virus Infection in Acute Hospitalized Patients Nature Communications. May, 2021 | Pubmed ID: 33976217 Exploration of a Sequential Gp140-Gp145 Immunization Regimen with Heterologous Envs to Induce a Protective Cross-Reactive HIV Neutralizing Antibody Response In Non-human Primates Virologica Sinica. Aug, 2021 | Pubmed ID: 33723807 Vaccinia Virus-based Vector Against Infectious Diseases and Tumors Human Vaccines & Immunotherapeutics. Jun, 2021 | Pubmed ID: 33606578 CagA Interacts with SHP-1 to Suppress the Immune Response by Targeting TRAF6 for K63-Linked Ubiquitination Journal of Immunology (Baltimore, Md. : 1950). Mar, 2021 | Pubmed ID: 33568397 IL-21 Arming Potentiates the Anti-tumor Activity of an Oncolytic Vaccinia Virus in Monotherapy and Combination Therapy Journal for Immunotherapy of Cancer. Jan, 2021 | Pubmed ID: 33504576 Current Status and Future Development of Anti-HIV Chimeric Antigen Receptor T-cell Therapy Immunotherapy. Feb, 2021 | Pubmed ID: 33225803 Correlation Between Early Plasma Interleukin 37 Responses With Low Inflammatory Cytokine Levels and Benign Clinical Outcomes in Severe Acute Respiratory Syndrome Coronavirus 2 Infection The Journal of Infectious Diseases. Feb, 2021 | Pubmed ID: 33197260 One-step Rapid Quantification of SARS-CoV-2 Virus Particles Via Low-cost Nanoplasmonic Sensors in Generic Microplate Reader and Point-of-care Device Biosensors & Bioelectronics. Jan, 2021 | Pubmed ID: 33113383 From Monovalent to Multivalent Vaccines, the Exploration for Potential Preventive Strategies Against Hand, Foot, and Mouth Disease (HFMD) Virologica Sinica. Apr, 2021 | Pubmed ID: 32997323 Freeze-Drying Formulations Increased the Adenovirus and Poxvirus Vaccine Storage Times and Antigen Stabilities Virologica Sinica. Jun, 2021 | Pubmed ID: 32696399 PD-L1 Chimeric Costimulatory Receptor Improves the Efficacy of CAR-T Cells for PD-L1-positive Solid Tumors and Reduces Toxicity in Vivo Biomarker Research. Nov, 2020 | Pubmed ID: 33292688 Engineering T Cells with Hypoxia-inducible Chimeric Antigen Receptor (HiCAR) for Selective Tumor Killing Biomarker Research. Oct, 2020 | Pubmed ID: 33292642 A Systemic Prime-Intrarectal Pull Strategy Raises Rectum-Resident CD8+ T Cells for Effective Protection in a Murine Model of LM-OVA Infection Frontiers in Immunology. 2020 | Pubmed ID: 33072113 CD160 Plays a Protective Role During Chronic Infection by Enhancing Both Functionalities and Proliferative Capacity of CD8+ T Cells Frontiers in Immunology. 2020 | Pubmed ID: 33072082 An Open-label, Randomized Trial of the Combination of IFN-κ Plus TFF2 with Standard Care in the Treatment of Patients with Moderate COVID-19 EClinicalMedicine. Oct, 2020 | Pubmed ID: 32984784 Placental Alkaline Phosphatase Promotes Zika Virus Replication by Stabilizing Viral Proteins Through BIP MBio. Sep, 2020 | Pubmed ID: 32934082 PEBP1 Suppresses HIV Transcription and Induces Latency by Inactivating MAPK/NF-κB Signaling EMBO Reports. Nov, 2020 | Pubmed ID: 32924251 Self-Assembly M2e-Based Peptide Nanovaccine Confers Broad Protection Against Influenza Viruses Frontiers in Microbiology. 2020 | Pubmed ID: 32922379 Mathematical Models for Devising the Optimal SARS-CoV-2 Strategy for Eradication in China, South Korea, and Italy Journal of Translational Medicine. Sep, 2020 | Pubmed ID: 32891155 A Clinical Pilot Study on the Safety and Efficacy of Aerosol Inhalation Treatment of IFN-κ Plus TFF2 in Patients with Moderate COVID-19 EClinicalMedicine. Aug, 2020 | Pubmed ID: 32838238 Internal Gene Cassette From a Human-Origin H7N9 Influenza Virus Promotes the Pathogenicity of H9N2 Avian Influenza Virus in Mice Frontiers in Microbiology. 2020 | Pubmed ID: 32793127 Correction To: Identification of MiRNA-mRNA Crosstalk in CD4 T Cells During HIV-1 Infection by Integrating Transcriptome Analyses Journal of Translational Medicine. Aug, 2020 | Pubmed ID: 32792010 Chemical Proteomics Tracks Virus Entry and Uncovers NCAM1 As Zika Virus Receptor Nature Communications. Aug, 2020 | Pubmed ID: 32753727 Human-IgG-Neutralizing Monoclonal Antibodies Block the SARS-CoV-2 Infection Cell Reports. Jul, 2020 | Pubmed ID: 32668215 A Benchmark Dataset of Protein Antigens for Antigenicity Measurement Scientific Data. Jul, 2020 | Pubmed ID: 32632108 Key Residues of the Receptor Binding Motif in the Spike Protein of SARS-CoV-2 That Interact with ACE2 and Neutralizing Antibodies Cellular & Molecular Immunology. Jun, 2020 | Pubmed ID: 32415260 IFN-κ Suppresses the Replication of Influenza A Viruses Through the IFNAR-MAPK-Fos-CHD6 Axis Science Signaling. Apr, 2020 | Pubmed ID: 32265337 Function-based High-throughput Screening for Antibody Antagonists and Agonists Against G Protein-coupled Receptors Communications Biology. Mar, 2020 | Pubmed ID: 32218528 Clinical and CT Features of Early Stage Patients with COVID-19: a Retrospective Analysis of Imported Cases in Shanghai, China The European Respiratory Journal. Apr, 2020 | Pubmed ID: 32217649 Identification of Potential Cross-protective Epitope Between a New Type of Coronavirus (2019-nCoV) and Severe Acute Respiratory Syndrome Virus Journal of Genetics and Genomics = Yi Chuan Xue Bao. Feb, 2020 | Pubmed ID: 32171450 Chinese Expert Consensus on the Perinatal and Neonatal Management for the Prevention and Control of the 2019 Novel Coronavirus Infection (First Edition) Annals of Translational Medicine. Feb, 2020 | Pubmed ID: 32154287 Escherichia Coli Adhesion Portion FimH Functions As an Adjuvant for Cancer Immunotherapy Nature Communications. Mar, 2020 | Pubmed ID: 32132528 The Immunologic Dominance of an Epitope Within a Rationally Designed Poly-epitope Vaccine is Influenced by Multiple Factors Vaccine. Mar, 2020 | Pubmed ID: 32127225 Identification of Specific Long Non-Coding Ribonucleic Acid Signatures and Regulatory Networks in Prostate Cancer in Fine-Needle Aspiration Biopsies Frontiers in Genetics. 2020 | Pubmed ID: 32117463 Induction of Cross-neutralizing Antibodies by Sequential Immunization with Heterologous Papillomavirus L1VLPs and Its Implications for HPV Prophylactic Vaccines Journal of Medical Virology. Dec, 2020 | Pubmed ID: 31994744 CD8α Conventional Dendritic Cells Control Vβ T-cell Immunity in Response to Staphylococcus Aureus Infection in Mice Immunology. Apr, 2020 | Pubmed ID: 31909831 Hepatomas Are Exquisitely Sensitive to Pharmacologic Ascorbate (P-AscH) Theranostics. 2019 | Pubmed ID: 31754384 Influenza Vaccine With Consensus Internal Antigens As Immunogens Provides Cross-Group Protection Against Influenza A Viruses Frontiers in Microbiology. 2019 | Pubmed ID: 31379782 Determination of Neutralization Activities by a New Versatile Assay Using an HIV-1 Genome Carrying the Gaussia Luciferase Gene Journal of Virological Methods. May, 2019 | Pubmed ID: 30817948 Pharmacologic Ascorbate As a Pro-drug for Hydrogen Peroxide Release to Kill Mycobacteria Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. Jan, 2019 | Pubmed ID: 30551469 Erratum To: Irreversible Phenotypic Perturbation and Functional Impairment of B Cells During HIV-1 Infection Frontiers of Medicine. Jun, 2019 | Pubmed ID: 29363037 Zinc-Finger Nucleases Induced by HIV-1 Tat Excise HIV-1 from the Host Genome in Infected and Latently Infected Cells Molecular Therapy. Nucleic Acids. Sep, 2018 | Pubmed ID: 30195798 Molecular Changes of Lung Malignancy in HIV Infection Scientific Reports. Sep, 2018 | Pubmed ID: 30177858 TSC1 and DEPDC5 Regulate HIV-1 Latency Through the MTOR Signaling Pathway Emerging Microbes & Infections. Aug, 2018 | Pubmed ID: 30087333 Single-Cell Approach to Influenza-Specific CD8 T Cell Receptor Repertoires Across Different Age Groups, Tissues, and Following Influenza Virus Infection Frontiers in Immunology. 2018 | Pubmed ID: 29997621 CE-BLAST Makes It Possible to Compute Antigenic Similarity for Newly Emerging Pathogens Nature Communications. May, 2018 | Pubmed ID: 29720583 Identification of Unequally Represented Founder Viruses Among Tissues in Very Early SIV Rectal Transmission Frontiers in Microbiology. 2018 | Pubmed ID: 29651274 Toward Universal Influenza Virus Vaccines: from Natural Infection to Vaccination Strategy Current Opinion in Immunology. Aug, 2018 | Pubmed ID: 29604600 Clonally Diverse CD38HLA-DRCD8 T Cells Persist During Fatal H7N9 Disease Nature Communications. Feb, 2018 | Pubmed ID: 29483513 AXL Promotes Zika Virus Infection in Astrocytes by Antagonizing Type I Interferon Signalling Nature Microbiology. Mar, 2018 | Pubmed ID: 29379210 Responses to Emerging and Re-emerging Infectious Diseases: One World, One Health Frontiers of Medicine. Feb, 2018 | Pubmed ID: 29363038 High Level of Neutrophil Extracellular Traps Correlates With Poor Prognosis of Severe Influenza A Infection The Journal of Infectious Diseases. Jan, 2018 | Pubmed ID: 29325098 Molecular Analyses of Prostate Tumors for Diagnosis of Malignancy on Fine-needle Aspiration Biopsies Oncotarget. Dec, 2017 | Pubmed ID: 29285211 The Bromodomain and Extraterminal Domain Inhibitor Bromosporine Synergistically Reactivates Latent HIV-1 in Latently Infected Cells Oncotarget. Nov, 2017 | Pubmed ID: 29212213 BET Inhibitors RVX-208 and PFI-1 Reactivate HIV-1 from Latency Scientific Reports. Nov, 2017 | Pubmed ID: 29192216 Irreversible Phenotypic Perturbation and Functional Impairment of B Cells During HIV-1 Infection Frontiers of Medicine. Dec, 2017 | Pubmed ID: 29181691 Reactivation of HIV-1 from Latency by an Ingenol Derivative from Euphorbia Kansui Scientific Reports. 08, 2017 | Pubmed ID: 28842560 Zika Virus Infects Renal Proximal Tubular Epithelial Cells with Prolonged Persistency and Cytopathic Effects Emerging Microbes & Infections. Aug, 2017 | Pubmed ID: 28831192 Fc Functional Antibodies in Humans with Severe H7N9 and Seasonal Influenza JCI Insight. Jul, 2017 | Pubmed ID: 28679958 A Novel Preventive Strategy Against HIV-1 Infection: Combinatorial Use of Inhibitors Targeting the Nucleocapsid and Fusion Proteins Emerging Microbes & Infections. Jun, 2017 | Pubmed ID: 28588284 Both Haemagglutinin-specific Antibody and T Cell Responses Induced by a Chimpanzee Adenoviral Vaccine Confer Protection Against Influenza H7N9 Viral Challenge Scientific Reports. May, 2017 | Pubmed ID: 28500340 Induction of Broadly Cross-Reactive Stalk-Specific Antibody Responses to Influenza Group 1 and Group 2 Hemagglutinins by Natural H7N9 Virus Infection in Humans The Journal of Infectious Diseases. 02, 2017 | Pubmed ID: 28380622 Sendai Virus Mucosal Vaccination Establishes Lung-Resident Memory CD8 T Cell Immunity and Boosts BCG-Primed Protection Against TB in Mice Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2017 | Pubmed ID: 28342639 MicroRNA MiR-126-5p Enhances the Inflammatory Responses of Monocytes to Lipopolysaccharide Stimulation by Suppressing Cylindromatosis in Chronic HIV-1 Infection Journal of Virology. May, 2017 | Pubmed ID: 28250134 Identification of MiRNA-mRNA Crosstalk in CD4 T Cells During HIV-1 Infection by Integrating Transcriptome Analyses Journal of Translational Medicine. Feb, 2017 | Pubmed ID: 28222782 Suppressor of Cytokine Signaling (SOCS)5 Ameliorates Influenza Infection Via Inhibition of EGFR Signaling ELife. Feb, 2017 | Pubmed ID: 28195529 Clinically Relevant Circulating MicroRNA Profiling Studies in Pancreatic Cancer Using Meta-analysis Oncotarget. Apr, 2017 | Pubmed ID: 28186984 Expression, Purification, and Renaturation of a Recombinant Peptide-based HIV Vaccine in Escherichia Coli Canadian Journal of Microbiology. Jun, 2017 | Pubmed ID: 28177783 Immune Signature of Enhanced Functional Avidity CD8 T Cells in Vivo Induced by Vaccinia Vectored Vaccine Scientific Reports. Feb, 2017 | Pubmed ID: 28155878 CD40 Agonist Converting CTL Exhaustion Via the Activation of the MTORC1 Pathway Enhances PD-1 Antagonist Action in Rescuing Exhausted CTLs in Chronic Infection Biochemical and Biophysical Research Communications. Mar, 2017 | Pubmed ID: 28153727 Nuclear Localization and Cleavage of STAT6 Is Induced by Kaposi's Sarcoma-Associated Herpesvirus for Viral Latency PLoS Pathogens. Jan, 2017 | Pubmed ID: 28099521 Characterization of Founder Viruses in Very Early SIV Rectal Transmission Virology. 02, 2017 | Pubmed ID: 28027479 Sequential Immunization with Consensus Influenza Hemagglutinins Raises Cross-reactive Neutralizing Antibodies Against Various Heterologous HA Strains Vaccine. Jan, 2017 | Pubmed ID: 27914743 On the Role of CD8 T Cells in Determining Recovery Time from Influenza Virus Infection Frontiers in Immunology. 2016 | Pubmed ID: 28066421 Immune Activation Influences SAMHD1 Expression and Vpx-mediated SAMHD1 Degradation During Chronic HIV-1 Infection Scientific Reports. Dec, 2016 | Pubmed ID: 27922067 Characterization of the Pathogenesis of H10N3, H10N7, and H10N8 Subtype Avian Influenza Viruses Circulating in Ducks Scientific Reports. Sep, 2016 | Pubmed ID: 27678170 Immune Repertoire Diversity Correlated with Mortality in Avian Influenza A (H7N9) Virus Infected Patients Scientific Reports. Sep, 2016 | Pubmed ID: 27669665 Human Mucosal-associated Invariant T Cells Contribute to Antiviral Influenza Immunity Via IL-18-dependent Activation Proceedings of the National Academy of Sciences of the United States of America. Sep, 2016 | Pubmed ID: 27543331 Follicular CXCR5- Expressing CD8(+) T Cells Curtail Chronic Viral Infection Nature. 08, 2016 | Pubmed ID: 27501245 Efficient Inhibition of Hepatitis B Virus Infection by a PreS1-binding Peptide Scientific Reports. Jul, 2016 | Pubmed ID: 27384014 Novel Exosome-targeted T-cell-based Vaccine Counteracts T-cell Anergy and Converts CTL Exhaustion in Chronic Infection Via CD40L Signaling Through the MTORC1 Pathway Cellular & Molecular Immunology. Jun, 2016 | Pubmed ID: 27264687 Next-Generation MRNA Sequencing Reveals Pyroptosis-Induced CD4+ T Cell Death in Early Simian Immunodeficiency Virus-Infected Lymphoid Tissues Journal of Virology. 01, 2016 | Pubmed ID: 26559826 Mucosal Topical Microbicide Candidates Exert Influence on the Subsequent SIV Infection and Survival by Regulating SIV-Specific T-Cell Immune Responses Journal of Acquired Immune Deficiency Syndromes (1999). Feb, 2016 | Pubmed ID: 26413849 Short Communication: The Distribution of Potential N-Linked Glycosylation Sites in Gp120 Differs Among Major HIV-1 Subtypes Circulating in China AIDS Research and Human Retroviruses. Jan, 2016 | Pubmed ID: 26384088 Successive Site Translocating Inoculation Potentiates DNA/recombinant Vaccinia Vaccination Scientific Reports. Dec, 2015 | Pubmed ID: 26667202 Evaluation of Anti-TBGL Antibody in the Diagnosis of Tuberculosis Patients in China Journal of Immunology Research. 2015 | Pubmed ID: 26339661 Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy Scientific Reports. 2015 | Pubmed ID: 26286358 Constitutive Activation of Interleukin-13/STAT6 Contributes to Kaposi's Sarcoma-Associated Herpesvirus-Related Primary Effusion Lymphoma Cell Proliferation and Survival Journal of Virology. Oct, 2015 | Pubmed ID: 26246572 Identification of Non-HIV Immunogens That Bind to Germline B12 Predecessors and Prime for Elicitation of Cross-clade Neutralizing HIV-1 Antibodies PloS One. 2015 | Pubmed ID: 26010511 [HIV/AIDS Related Mortality in Southern Shanxi Province and Its Risk Factors] Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi. Mar, 2015 | Pubmed ID: 25975402 Recovery from Severe H7N9 Disease is Associated with Diverse Response Mechanisms Dominated by CD8⁺ T Cells Nature Communications. May, 2015 | Pubmed ID: 25967273 The Upregulation of LAG-3 on T Cells Defines a Subpopulation with Functional Exhaustion and Correlates with Disease Progression in HIV-infected Subjects Journal of Immunology (Baltimore, Md. : 1950). Apr, 2015 | Pubmed ID: 25780040 Hepatitis B Virus and Hepatitis C Virus Infection Among HIV-1-infected Injection Drug Users in Dali, China: Prevalence and Infection Status in a Cross-sectional Study Archives of Virology. Apr, 2015 | Pubmed ID: 25616842 Transgenic 4-1BBL-engineered Vaccine Stimulates Potent Gag-specific Therapeutic and Long-term Immunity Via Increased Priming of CD44(+)CD62L(high) IL-7R(+) CTLs with Up- and Downregulation of Anti- and Pro-apoptosis Genes Cellular & Molecular Immunology. Jul, 2015 | Pubmed ID: 25195511 Drug Susceptibility Profile and Pathogenicity of H7N9 Influenza Virus (Anhui1 Lineage) with R292K Substitution Emerging Microbes & Infections. Nov, 2014 | Pubmed ID: 26038501 Willingness to Participate in HIV Therapeutic Vaccine Trials Among HIV-infected Patients on ART in China PloS One. 2014 | Pubmed ID: 25372044 IFN-stimulated Gene LY6E in Monocytes Regulates the CD14/TLR4 Pathway but Inadequately Restrains the Hyperactivation of Monocytes During Chronic HIV-1 Infection Journal of Immunology (Baltimore, Md. : 1950). Oct, 2014 | Pubmed ID: 25225669 Virus-host Mucosal Interactions During Early SIV Rectal Transmission Virology. Sep, 2014 | Pubmed ID: 25128762 Glioma-associated Antigen HEATR1 Induces Functional Cytotoxic T Lymphocytes in Patients with Glioma Journal of Immunology Research. 2014 | Pubmed ID: 25126583 Fusion-expressed CTB Improves Both Systemic and Mucosal T-cell Responses Elicited by an Intranasal DNA Priming/intramuscular Recombinant Vaccinia Boosting Regimen Journal of Immunology Research. 2014 | Pubmed ID: 24741585 As a Genetic Adjuvant, CTA Improves the Immunogenicity of DNA Vaccines in an ADP-ribosyltransferase Activity- and IL-6-dependent Manner Vaccine. Apr, 2014 | Pubmed ID: 24631089 CTL Responses to HSP47 Associated with the Prolonged Survival of Patients with Glioblastomas Neurology. Apr, 2014 | Pubmed ID: 24623841 Boosting Functional Avidity of CD8+ T Cells by Vaccinia Virus Vaccination Depends on Intrinsic T-cell MyD88 Expression but Not the Inflammatory Milieu Journal of Virology. May, 2014 | Pubmed ID: 24554667 Differential Compartmentalization of HIV-targeting Immune Cells in Inner and Outer Foreskin Tissue PloS One. 2014 | Pubmed ID: 24454812 Epidemiologic Report and Serologic Findings for Household Contacts of Three Cases of Influenza A (H7N9) Virus Infection Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology. Feb, 2014 | Pubmed ID: 24388209 Early Hypercytokinemia is Associated with Interferon-induced Transmembrane Protein-3 Dysfunction and Predictive of Fatal H7N9 Infection Proceedings of the National Academy of Sciences of the United States of America. Jan, 2014 | Pubmed ID: 24367104 Recruitment of HIV-1 Target Cells at Topical Mucosal Sites: a Sensitive and Early Marker for Determining the Safety of Microbicide Candidates Emerging Microbes & Infections. Jul, 2013 | Pubmed ID: 26038476 [HIV-1 Infection Up-regulating Expression of Interferon-stimulated Gene 15 in Cell Lines] Bing Du Xue Bao = Chinese Journal of Virology. Sep, 2013 | Pubmed ID: 24386835 Multiple Independent Introductions of HIV-1 CRF01_AE Identified in China: What Are the Implications for Prevention? PloS One. 2013 | Pubmed ID: 24282546 MCPIP1 Restricts HIV Infection and is Rapidly Degraded in Activated CD4+ T Cells Proceedings of the National Academy of Sciences of the United States of America. Nov, 2013 | Pubmed ID: 24191027 The Potential of the Human Immune System to Develop Broadly Neutralizing HIV-1 Antibodies: Implications for Vaccine Development AIDS (London, England). Oct, 2013 | Pubmed ID: 24100711 Safe Pseudovirus-based Assay for Neutralization Antibodies Against Influenza A(H7N9) Virus Emerging Infectious Diseases. Oct, 2013 | Pubmed ID: 24047684 PA-356R is a Unique Signature of the Avian Influenza A (H7N9) Viruses with Bird-to-human Transmissibility: Potential Implication for Animal Surveillances The Journal of Infection. Nov, 2013 | Pubmed ID: 23933287 Serological Investigation of Subclinical Influenza A(H7H9) Infection Among Healthcare and Non-healthcare Workers in Zhejiang Province, China Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Sep, 2013 | Pubmed ID: 23759348 Potent T Cell Responses Induced by Single DNA Vaccine Boosted with Recombinant Vaccinia Vaccine Virologica Sinica. Apr, 2013 | Pubmed ID: 23575733 Identification of Dominant Antibody-dependent Cell-mediated Cytotoxicity Epitopes on the Hemagglutinin Antigen of Pandemic H1N1 Influenza Virus Journal of Virology. May, 2013 | Pubmed ID: 23487456 New Emerging Recombinant HIV-1 Strains and Close Transmission Linkage of HIV-1 Strains in the Chinese MSM Population Indicate a New Epidemic Risk PloS One. 2013 | Pubmed ID: 23372706 Responses to Multiple Injections with Alum Alone Compared to Injections with Alum Adsorbed to Proteins in Mice Immunology Letters. Jan, 2013 | Pubmed ID: 23183095 Five New CRF07_BC Near Full-length Sequences Isolated from Sichuan, China AIDS Research and Human Retroviruses. Jan, 2013 | Pubmed ID: 22931113 A New Migration Map of HIV-1 CRF07_BC in China: Analysis of Sequences from 12 Provinces over a Decade PloS One. 2012 | Pubmed ID: 23300654 The Average IFN-γ Secreting Capacity of Specific CD8(+) T Cells is Compromised While Increasing Copies of a Single T Cell Epitope Encoded by DNA Vaccine Clinical & Developmental Immunology. 2012 | Pubmed ID: 23251217 Development of Skewed Functionality of HIV-1-specific Cytotoxic CD8(+) T Cells from Primary to Early Chronic Phase of HIV Infection PloS One. 2012 | Pubmed ID: 23028721 Immunization with HBsAg-Fc Fusion Protein Induces a Predominant Production of Th1 Cytokines and Reduces HBsAg Level in Transgenic Mice Chinese Medical Journal. Sep, 2012 | Pubmed ID: 22964321 In Vitro Infection of Human Umbilical Cord Blood CD34+ Hematopoietic Progenitor Cells by HIV-1 CRF07_BC Enveloped Pseudovirus Current HIV Research. Oct, 2012 | Pubmed ID: 22934658 Minocycline Down-regulates Topical Mucosal Inflammation During the Application of Microbicide Candidates PloS One. 2012 | Pubmed ID: 22905236 Efficacy, Stability, and Biosafety of Sifuvirtide Gel As a Microbicide Candidate Against HIV-1 PloS One. 2012 | Pubmed ID: 22615996 Boosting Heterosubtypic Neutralization Antibodies in Recipients of 2009 Pandemic H1N1 Influenza Vaccine Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Jan, 2012 | Pubmed ID: 22052887 Near Full-length Sequence Analysis of Two New HIV Type 1 Unique (CRF01_AE/B) Recombinant Forms Among Men Who Have Sex with Men in China AIDS Research and Human Retroviruses. Apr, 2012 | Pubmed ID: 21902589 Chloramphenicol Improved Expression of Recombinant Cholera Toxin B Subunit in Escherichia Coli and Its Adjuvanticity Chinese Medical Journal. Sep, 2011 | Pubmed ID: 22040436 Early Adaptive Humoral Immune Responses and Virus Clearance in Humans Recently Infected with Pandemic 2009 H1N1 Influenza Virus PloS One. 2011 | Pubmed ID: 21886767 [Establishment of Human Colorectal Tissue Model in HIV-1 Mucosal Infection] Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine]. Feb, 2011 | Pubmed ID: 21426791 A New Approach for Sequencing Virion Genome of Chinese HIV-1 Strains Subtype B and BC from Plasma Chinese Medical Journal. Jan, 2011 | Pubmed ID: 21362385 Transmission of New CRF07_BC Strains with 7 Amino Acid Deletion in Gag P6 Virology Journal. 2011 | Pubmed ID: 21306651 Transcriptional Analysis of Immune-related Genes in Dendritic Cells from Hepatitis B Surface Antigen (HBsAg)-positive Transgenic Mice and Regulation of Fc Gamma Receptor IIB by HBsAg-anti-HBs Complex Journal of Medical Virology. Jan, 2011 | Pubmed ID: 21108342 HIV/AIDS Vaccine Development: Are We Walking out from the Dark? Chinese Medical Journal. Dec, 2010 | Pubmed ID: 22166537 Establishing a Th17 Based Mouse Model for Preclinical Assessment of the Toxicity of Candidate Microbicides Chinese Medical Journal. Dec, 2010 | Pubmed ID: 22166518 Deglycosylation of HIV-1 AE Gp140 Enhances the Capacity to Elicit Neutralizing Antibodies Against the Heterologous HIV-1 Clade AIDS Research and Human Retroviruses. May, 2010 | Pubmed ID: 20455767 HCV Coinfection Associated with Slower Disease Progression in HIV-infected Former Plasma Donors Naïve to ART PloS One. 2008 | Pubmed ID: 19098990 HIV-1/AIDS Vaccine Development: Are We in the Darkness Chinese Medical Journal. May, 2008 | Pubmed ID: 18706210 Generation and Functional Verification of Hypoxia-sensitive Chimeric Antigen Receptor-T Cells Ying Xue*1, Yunyu Mao*2, Qibin Liao3, Chen Zhao4, Xiaoyan Zhang1,2,4, Jianqing Xu1,2,4 1Institutes of Biomedical Sciences, Fudan University, 2Clinical Center of Biotherapy at Zhongshan Hospital, Fudan University, 3Department of Oncology and Bio-therapeutic Center, Shenzhen Third People's Hospital, Southern University of Science and Technology, 4Shanghai Public Health Clinical Center, Fudan University JoVE 66697 Ricerca sul cancro
Generation and Functional Verification of Hypoxia-sensitive Chimeric Antigen Receptor-T Cells Ying Xue*1, Yunyu Mao*2, Qibin Liao3, Chen Zhao4, Xiaoyan Zhang1,2,4, Jianqing Xu1,2,4 1Institutes of Biomedical Sciences, Fudan University, 2Clinical Center of Biotherapy at Zhongshan Hospital, Fudan University, 3Department of Oncology and Bio-therapeutic Center, Shenzhen Third People's Hospital, Southern University of Science and Technology, 4Shanghai Public Health Clinical Center, Fudan University JoVE 66697 Ricerca sul cancro