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Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples
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Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples
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October 23, 2020
DOI:
1Department of Anesthesiology and Critical Care, Soroka Medical Center,Ben-Gurion University of the Negev, 2Department of Anesthesiology,Yale University School of Medicine, 3Department of Neurosurgery, Soroka University Medical Center and the Faculty of Health Sciences,Ben-Gurion University of the Negev, 4Department of Physiology, Faculty of Biology, Ecology and Medicine,Dnepropetrovsk State University
Summary
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This protocol describes a novel technique of measuring the three most important parameters of ischemic brain injury on the same set of rodent brain samples. Using only one brain sample is highly advantageous in terms of ethical and economic costs.
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Frank, D., Gruenbaum, B. F., Grinshpun, J., Melamed, I., Severynovska, O., Kuts, R., Semyonov, M., Brotfain, E., Zlotnik, A., Boyko, M. Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples. J. Vis. Exp. (164), e61309, doi:10.3791/61309 (2020).
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