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A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
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Génétique
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Journal JoVE Génétique
A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

DOI:
10.3791/61268-v

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05:01 min

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July 01, 2020

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1Institute for Genomics, Biocomputing & Biotechnology,Mississippi State University, 2Corn Host Plant Resistance Research Unit,USDA-ARS

Chapitres

  • 00:05Introduction
  • 00:32Genome-Wide Association Study (GWAS) Data Loading
  • 00:57Load Linkage Disequilibrium (LD) Data Loading
  • 01:26Single Nucleotide Polymorphism (SNP) Assignment
  • 01:56Significant Pathway Discovery
  • 02:35Rugplot Visualization
  • 03:21Results: Representative GWAS Analyses of Metabolic Pathway Information
  • 04:21Conclusion

Summary

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By running the Pathway Association Study Tool (PAST), either through the Shiny application or through the R console, researchers can gain a deeper understanding of the biological meaning of their genome-wide association study (GWAS) results by investigating the metabolic pathways involved.

Tags

GWASGenome-wide Association AnalysisMetabolic PathwayPASTPathway Association Study ToolSNPsLinkage DisequilibriumGene AnnotationPathway AnalysisRug PlotsR ConsoleShiny

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