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January 12, 2020
DOI:
1Department of Pharmacology and Toxicology,University of Louisville, 2Hepatobiology and Toxicology Program,University of Louisville, 3Department of Physiology and Pharmacology,West Virginia University, 4Center for Inhalation Toxicology,West Virginia University, 5Department of Pharmacology and Chemical Biology,University of Pittsburgh, 6Pittsburgh Liver Research Center,University of Pittsburgh, 7Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition,University of Pittsburgh
Summary
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该协议的目标是开发一种低水平毒性暴露的鼠模型，不会造成公开肝损伤，反而会加剧先前存在的肝损伤。这种模式更好地概括了人类接触和接触被认为是安全的毒物浓度时发生的微妙变化。
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Lang, A. L., Goldsmith, W. T., Schnegelberger, R. D., Arteel, G. E., Beier, J. I. Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction. J. Vis. Exp. (155), e60351, doi:10.3791/60351 (2020).
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