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重组流感疫苗的嵌合体小鼠模型鼻腔给药研究黏膜免疫
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10:39 min
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June 25, 2015
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There is an overall lack of knowledge about how vaccines work. Here we propose the combined use of reverse genetics and bone marrow chimeric mice to gain insight into the early host immune responses to vaccines with a special focus on dendritic cells and T cell immunity.
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Pérez-Girón, J. V., Gómez-Medina, S., Lüdtke, A., Munoz-Fontela, C. Intranasal Administration of Recombinant Influenza Vaccines in Chimeric Mouse Models to Study Mucosal Immunity. J. Vis. Exp. (100), e52803, doi:10.3791/52803 (2015).
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