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Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury
Journal JoVE
Neurosciences
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Journal JoVE Neurosciences
Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury
DOI:

09:56 min

July 27, 2014

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Chapitres

  • 00:05Titre
  • 01:51T3 Spinal Cord Transection
  • 04:25Preparation of Spinal Cord Neural Stem Cells
  • 06:22Transplantation of Cells into Spinal Cord Lesion
  • 07:29Results: Grafted Cell Survival and Morphology
  • 09:31Conclusion

Summary

Traduction automatique

Fibrin matrices containing growth factors were used to retain grafted neural stem cells into sites of complete spinal cord transection. Grafted cells completely filled the lesion cavity and differentiated into multiple neural cell types, including neurons that extended axons into host spinal cord over long distances.

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