Xian Aier Eye Hospital 1 article published in JoVE Medicine Iris Fixation via External Pentagram Suturing Xiang Fan1,2, Yansheng Hao1,3, Ying Chu1,2, Jing Hong1,2 1Department of Ophthalmology, Peking University Third Hospital, 2Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, 3Xian Aier Eye Hospital The present protocol describes how a 10-0 polypropylene suture crosses the anterior surface of the iris, forming a pentagram to prevent both iris and pupil from moving toward the cornea. This can be combined with subsequent keratoplasty to cure bullous keratopathy with extensive anterior synechia of the iris.