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Author Spotlight: Enhancing Cryo-Electron Microscopy by Automated Data Collection and Analysis Techniques

JoVE Revista
Bioquímica

This content is Free Access.

JoVE Revista Bioquímica

Cryo-Electron Microscopy Screening Automation Across Multiple Grids Using Smart Leginon

Author Spotlight: Enhancing Cryo-Electron Microscopy by Automated Data Collection and Analysis Techniques

439 Views

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01:41 min

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December 01, 2023

DOI:

10.3791/66007-v

DOI:

10.3791/66007-v

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01:41 min

December 01, 2023

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6 Views

Anjelique Sawh-Gopal², Aygul Ishemgulova*¹, Eugene Y. D. Chua*¹, Mahira F. Aragon*¹, Joshua H. Mendez, Edward T. Eng, Alex J. Noble

¹Simons Electron Microscopy Center, New York Structural Biology Center, ²Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology

Tags

Cryo-electron Microscopy Screening Automation Smart Leginon Data Collection Data Analysis Machine Learning Particle Picking 3D Flexibility Analysis Model Building Grid Screening Sample Preparation CryoEM Workflow Structural Biology Macromolecular Protein Complexes Grid Optimization

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