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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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January 21, 2020
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This article presents a protocol for establishing a ligature-induced model of murine periodontitis involving multiple maxillary molars, resulting in larger areas of the involved gingival tissue and bone for subsequent analysis as well as reduced animal usage. A technique to assess oral neutrophils in a manner analogous to human subjects is also described.
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Chadwick, J. W., Glogauer, M. Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils. J. Vis. Exp. (155), e59667, doi:10.3791/59667 (2020).
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