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ジカ ウイルス特異 Immunoprivileged 臓器感染 Ifnar1-/-マウスの T 細胞応答の評価
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October 17, 2018
DOI:
1School of Laboratory Medicine and Life Sciences,Wenzhou Medical University, 2NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention, 3State Key Laboratory of Agrobiotechnology, College of Biological Sciences,China Agricultural University, 4Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science,Chinese Academy of Sciences, 5Laboratory Animal Center,Chinese Center for Disease Control and Prevention, 6CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology,Chinese Academy of Sciences
Summary
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ジカ ウイルス (ZIKV) のための Ifnar1-/-マウスのモデルの immunoprivileged 器官の抗原特異的 T 細胞応答を評価するためのプロトコルを説明します。このメソッドは、有効性評価の貴重なも ZIKV ワクチンの免疫病態と保護細胞メカニズムを調査するために極めて重要です。
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Cite this Article
Zhang, Y., Zhang, H., Ma, W., Liu, K., Zhao, M., Zhao, Y., Lu, X., Zhang, F., Li, X., Gao, G. F., Liu, W. J. Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice. J. Vis. Exp. (140), e58110, doi:10.3791/58110 (2018).
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