/
/
Vurdering af den cytotoksiske og immunmodulerende virkninger af stoffer i menneskelige præcision-cut lunge skiver
This content is Free Access.
Vurdering af den cytotoksiske og immunmodulerende virkninger af stoffer i menneskelige præcision-cut lunge skiver
13,145 Views
•
12:04 min
•
May 09, 2018
DOI:
1Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), German Center for Lung Research (DZL),Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of REBIRTH Cluster of Excellence, 2Institute for Pathology, Hannover Medical School, German Center for Lung Research (DZL),Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), 3Division of Thoracic and Vascular Surgery,Klinikum Region Hannover (KRH), 4Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), Hannover Medical School, German Center for Lung Research (DZL),Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), 5Institute of Pharmacology and Toxicology,RWTH Aachen University, 6Institute for Immunology,Hannover Medical School
Summary
Automatically generated
I betragtning af 3R-princippet, respiratorisk modeller som alternativer til dyreforsøg er under udvikling. Især for risikovurdering af respiratorisk stoffer er der en mangel på passende assays. Her, beskriver vi brugen af menneskelige præcision-cut lunge skiver til vurdering af luftbårne stoffer.
Read Article
Cite this Article
Neuhaus, V., Danov, O., Konzok, S., Obernolte, H., Dehmel, S., Braubach, P., Jonigk, D., Fieguth, H., Zardo, P., Warnecke, G., Martin, C., Braun, A., Sewald, K. Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices. J. Vis. Exp. (135), e57042, doi:10.3791/57042 (2018).
Copy