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对于拟肽与他们抗利什曼原虫活性混合赖氨酸型/精氨酸型单体及评价合成的有效方法
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Bioquímica
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JoVE Revista Bioquímica
An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
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对于拟肽与他们抗利什曼原虫活性混合赖氨酸型/精氨酸型单体及评价合成的有效方法

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12:02 min

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November 02, 2016

DOI:

10.3791/54750-v

DOI:
10.3791/54750-v

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12:02 min
November 02, 2016

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2 Views
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1Department of Chemistry,Durham University, 2School of Medicine, Pharmacy and Health,Durham University

Summary

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A protocol to synthesize peptoids with mixed cationic functionality in the same sequence is presented (lysine- and arginine-type monomers). Subsequent testing of these compounds against Leishmania mexicana, the protozoan parasites that cause cutaneous leishmaniasis, is also described.

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PeptoidsLysineArginineAnti-leishmanial ActivityCutaneous LeishmaniasisLeishmania MexicanaSubmonomer SynthesisFmoc-protected ResinPiperidineBromoacetic AcidDICAmine Solution

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Bolt, H. L., Denny, P. W., Cobb, S. L. An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity. J. Vis. Exp. (117), e54750, doi:10.3791/54750 (2016).

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