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장간막 림프 덕트 유관 쥐 모델 : 창자 림프 약물 운송의 평가에 응용
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Inmunología y contagio
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JoVE Revista Inmunología y contagio
The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport
Please note that all translations are automatically generated. Click here for the English version.

장간막 림프 덕트 유관 쥐 모델 : 창자 림프 약물 운송의 평가에 응용

27,926 Views

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13:17 min

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March 06, 2015

DOI:

10.3791/52389-v

DOI:
10.3791/52389-v

•

13:17 min
March 06, 2015

•

38 Views
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1Drug Delivery, Disposition, and Dynamics, Monash Institute of Pharmaceutical Sciences,Monash University (Parkville Campus)

Summary

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Here we describe a technique to cannulate the mesenteric lymph duct in rats which enables quantification of lipid and drug transport via the lymphatic system following intestinal delivery. The technique can be adapted to assess mesenteric lymph concentrations and/or transport of fluid, immune cells, peptides, proteins and lipophilic molecules.

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Mesenteric Lymph DuctIntestinal Lymphatic SystemLymph FlowLymph CompositionLymphatic Drug TransportLymph CannulationRat Model

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Trevaskis, N. L., Hu, L., Caliph, S. M., Han, S., Porter, C. J. The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport. J. Vis. Exp. (97), e52389, doi:10.3791/52389 (2015).

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