Journal
/
Biología del desarrollo
/
Umano cellule staminali pluripotenti Basato Tossicità per lo sviluppo saggi per Chemical Screening e Safety Systems Biology generazione dati
JoVE Revista
Biología del desarrollo
Se requiere una suscripción a JoVE para ver este contenido.  Inicie sesión o comience su prueba gratuita.
JoVE Revista Biología del desarrollo
Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
Please note that all translations are automatically generated. Click here for the English version.

Umano cellule staminali pluripotenti Basato Tossicità per lo sviluppo saggi per Chemical Screening e Safety Systems Biology generazione dati

12,368 Views

•

17:28 min

•

June 17, 2015

DOI:

10.3791/52333-v

DOI:
10.3791/52333-v

•

17:28 min
June 17, 2015

•

3 Views
, , , , , , , , , , ,
1Center of Physiology and Pathophysiology, Institute of Neurophysiology,University of Cologne, 2Department of Biology,University of Konstanz, 3Department of Statistics,Technical University of Dortmund, 4Leibniz Research Centre for Working Environment and Human Factors,Technical University of Dortmund

Summary

Automatically generated

I protocolli descrivono due sistemi di test in vitro di tossicità dello sviluppo (UKK e UKN1) a base di cellule staminali embrionali umane e studi trascrittoma. I sistemi di test prevedono pericolo tossicità per lo sviluppo umano, e possono contribuire a ridurre studi sugli animali, i costi e il tempo necessario per le prove della sicurezza chimica.

Explore More Videos

Human Pluripotent Stem CellsDevelopmental Toxicity AssaysChemical Safety ScreeningSystems BiologyEmbryonic Stem CellsEmbryoid BodiesNeuroectodermal Progenitor CellsTranscriptome MicroarrayIn Vitro Toxicity TestingEarly Embryonic ToxicityTeratogenicityDevelopmental NeurotoxicityEpigenetic ChangesToxicity BiomarkersSystems Biology AnalysisAnimal Studies ReductionDrug DevelopmentChemical Safety Evaluation

Read Article

Cite this Article

Shinde, V., Klima, S., Sureshkumar, P. S., Meganathan, K., Jagtap, S., Rempel, E., Rahnenführer, J., Hengstler, J. G., Waldmann, T., Hescheler, J., Leist, M., Sachinidis, A. Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation. J. Vis. Exp. (100), e52333, doi:10.3791/52333 (2015).

Download .ris file

Copy

Share Video

.

Copy