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تقييم الفئران تمرين التحمل من دون استخدام الشبكة من الصدمة: بديل لممارسة القسري
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Assessment of Murine Exercise Endurance Without the Use of a Shock Grid: An Alternative to Forced Exercise
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تقييم الفئران تمرين التحمل من دون استخدام الشبكة من الصدمة: بديل لممارسة القسري

18,677 Views

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07:52 min

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August 14, 2014

DOI:

10.3791/51846-v

DOI:
10.3791/51846-v

•

07:52 min
August 14, 2014

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10 Views
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1Research Service,VA Puget Sound Health Care System, 2Seattle Institute for Biomedical and Clinical Research, 3Division of Gerontology and Geriatric Medicine, Department of Medicine,University of Washington, 4Geriatric Research, Education, and Clinical Center,VA Puget Sound Health Care System

Summary

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A method to assess exercise endurance in laboratory mice without the use of a shock grid is demonstrated. This method is a humane refinement that can decrease the confounding effects of stress on experimental parameters.

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Exercise EnduranceMurine ModelTreadmillShock GridVoluntary RunningBehavioral CuesTime-to-exhaustionStress ReductionExperimental Refinement

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Conner, J. D., Wolden-Hanson, T., Quinn, L. S. Assessment of Murine Exercise Endurance Without the Use of a Shock Grid: An Alternative to Forced Exercise. J. Vis. Exp. (90), e51846, doi:10.3791/51846 (2014).

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