A method to assess exercise endurance in laboratory mice without the use of a shock grid is demonstrated. This method is a humane refinement that can decrease the confounding effects of stress on experimental parameters.
Conner, J. D., Wolden-Hanson, T., Quinn, L. S. Assessment of Murine Exercise Endurance Without the Use of a Shock Grid: An Alternative to Forced Exercise. J. Vis. Exp. (90), e51846, doi:10.3791/51846 (2014).