Generation of T lymphocytes from induced pluripotent stem (iPS) cells gives an alternative approach of using embryonic stem cells for T cell-based immunotherapy. The method shows that by utilizing either in vitro or in vivo induction system, iPS cells are able to differentiate into both conventional and antigen-specific T lymphocytes.
Lei, F., Haque, R., Xiong, X., Song, J. Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes. J. Vis. Exp. (63), e3986, doi:10.3791/3986 (2012).