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Karşı Önceden tanımlanmış T Hücre Reseptör özgüllükleri Transnuclear Fare Toxoplasma gondii SCNT ile Elde Edilen
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Inmunología y contagio
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JoVE Revista Inmunología y contagio
Transnuclear Mice with Pre-defined T Cell Receptor Specificities Against Toxoplasma gondii Obtained Via SCNT
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Karşı Önceden tanımlanmış T Hücre Reseptör özgüllükleri Transnuclear Fare Toxoplasma gondii SCNT ile Elde Edilen

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13:36 min

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September 30, 2010

DOI:

10.3791/2168-v

DOI:
10.3791/2168-v

•

13:36 min
September 30, 2010

•

2 Views
, , , , ,
1Whitehead Institute for Biomedical Research, 2Departments of Microbiology and Biological Sciences,National University of Singapore, 3Department of Biology,Massachusetts Institute of Technology

Summary

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Somatik Hücre Nükleer Transferi (SCNT) üzerinden epigenetik yeniden programlama önceden tanımlanmış T hücre reseptör (TCR) özgüllükleri fare modelleri oluşturmak için bir araç olarak kullanılabileceğini göstermektedir. Bu transnuclear fareler, endojen endojen organizatörü kontrol altında lokus karşılık gelen TCR ifade eder.

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Kirak, O., Frickel, E., Grotenbreg, G. M., Suh, H., Jaenisch, R., Ploegh, H. L. Transnuclear Mice with Pre-defined T Cell Receptor Specificities Against Toxoplasma gondii Obtained Via SCNT. J. Vis. Exp. (43), e2168, doi:10.3791/2168 (2010).

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