Restorative Neurosciences Foundation 1 article published in JoVE Medicine Image-guided Convection-enhanced Delivery into Agarose Gel Models of the Brain Karl A. Sillay1,2, S. Gray McClatchy3, Brandon A. Shepherd1, Garrett T. Venable1, Tyler S. Fuehrer4 1University of Tennessee Health Science Center, 2Semmes-Murphey Clinic, 3University of Arkansas for Medical Sciences, 4Restorative Neurosciences Foundation Convection-enhanced delivery (CED) has been proposed as a treatment option for a wide range of neurological diseases. In order to prepare health care professionals for adoption of CED, accessible training models are needed. We describe the use of agarose gel as such a model of the human brain for testing, research, and training.