Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish

Vadim Le Joncour; Sinem Karaman; Pirjo  Maarit Laakkonen

doi:10.3791/59384

Journal

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Krebsforschung

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Fornitura di payload predicting In Vivo utilizzando una tumore-barriera emato-encefalica in un piatto

JoVE Journal
Krebsforschung

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JoVE Journal Krebsforschung

Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish

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Fornitura di payload predicting In Vivo utilizzando una tumore-barriera emato-encefalica in un piatto

8,792 Views

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13:34 min

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April 16, 2019

DOI:

10.3791/59384-v

DOI:

10.3791/59384-v

•

13:34 min

April 16, 2019

•

3 Views

Vadim Le Joncour¹, Sinem Karaman^1,2, Pirjo Maarit Laakkonen^1,3

¹Research Programs Unit, Translational Cancer Medicine Research Program,University of Helsinki, ²Wihuri Research Institute, Biomedicum Helsinki,University of Helsinki, ³Laboratory Animal Center, Helsinki Institute of Life Science (HiLIFE),University of Helsinki

Summary

Drug targeting per tumori del sistema nervoso centrale è una sfida importante. Qui descriviamo un protocollo per produrre un mimo in vitro del tumore-barriera emato-encefalica utilizzando cellule murine e/o umane e discutere la loro rilevanza per la prevedibilità del sistema nervoso centrale targeting tumorale in vivo.

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Fornitura di payload predicting In Vivo utilizzando una tumore-barriera emato-encefalica in un piatto

Summary

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