Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish

Vadim Le Joncour; Sinem Karaman; Pirjo  Maarit Laakkonen

doi:10.3791/59384

Journal

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Krebsforschung

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Prediciendo en Vivo cargas entrega usando una Barrera Blood-brain Tumor en un plato

JoVE Journal
Krebsforschung

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JoVE Journal Krebsforschung

Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish

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Prediciendo en Vivo cargas entrega usando una Barrera Blood-brain Tumor en un plato

8,792 Views

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13:34 min

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April 16, 2019

DOI:

10.3791/59384-v

DOI:

10.3791/59384-v

•

13:34 min

April 16, 2019

•

3 Views

Vadim Le Joncour¹, Sinem Karaman^1,2, Pirjo Maarit Laakkonen^1,3

¹Research Programs Unit, Translational Cancer Medicine Research Program,University of Helsinki, ²Wihuri Research Institute, Biomedicum Helsinki,University of Helsinki, ³Laboratory Animal Center, Helsinki Institute of Life Science (HiLIFE),University of Helsinki

Summary

Medicamentos dirigidos a tumores del sistema nervioso central es un gran desafío. Aquí se describe un protocolo para producir a un imitador in vitro de la tumor-barrera blood-brain con células murinas y humanas y discutir su pertinencia para la previsibilidad del sistema nervioso central tumor targeting in vivo.

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Prediciendo en Vivo cargas entrega usando una Barrera Blood-brain Tumor en un plato

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