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Α-Imino γ-Lactones의 Organocatalytic Cycloadditions 및 Alkylidene Pyrazolones 통해 마약 같은 Bispirocyclic 장비의 효율적인 건설
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February 07, 2019
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Enantiomerically 농축된 bispiro [γ-butyrolactone-pyrrolidin-4, 4'-pyrazolone] 해골 비대칭으로 간단한 organocatalytic 1, 3 배위 cycloaddition 반응을 통해 합성 됩니다.
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Keyword Extraction:Drug-like Bispirocyclic ScaffoldsOrganocatalytic Cycloadditionsα-imino γ-lactonesAlkylidene PyrazolonesBipolar CycloadditionBispirocyclic CompoundsNatural ProductsBiological ActivitiesChiral Spiral CentersHigh YieldsStereoselectivityPyrazoloneHydrazineEthyl Acetoacetateα-arylidiene PyrazolinoneBenzaldehydeMagnesium OxideAcetonitrile
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Zhou, Y., Chen, N., Cheng, Y., Cai, X. Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones. J. Vis. Exp. (144), e59155, doi:10.3791/59155 (2019).
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