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诱导多潜能干细胞源性肝细胞的家族性高胆固醇血症人肝嵌合小鼠模型
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10:56 min
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September 15, 2018
DOI:
1Department of Medicine,University of Hong Kong-Shenzhen Hospital, 2The Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine,University of Hong Kong, 3School of Biomedical Sciences, Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences,Chinese University of Hong Kong, 4Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences, Joint School of Life Sciences,Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University, 5Laboratory of RNA, Chromatin, and Human Disease, CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences, 6Research Centre of Heart, Brain, Hormone, and Healthy Ageing, Li Ka Shing Faculty of Medicine,University of Hong Kong, 7Hong Kong-Guangdong Stem Cell and Regenerative Medicine Research Centre,University of Hong Kong and Guangzhou Institutes of Biomedicine and Health
Summary
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在这里, 我们提出了一个协议, 以生成一个人肝嵌合体小鼠家庭高胆固醇血症使用人诱导的多潜能干细胞源性肝细胞模型。这是一个有价值的模型来测试新的治疗高胆固醇血症。
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Cite this Article
Yang, J., Wong, L., Tian, X., Wei, R., Lai, W., Au, K., Luo, Z., Ward, C., Ho, W., Ibañez, D. P., Liu, H., Bao, X., Qin, B., Huang, Y., Esteban, M. A., Tse, H. A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes. J. Vis. Exp. (139), e57556, doi:10.3791/57556 (2018).
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