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Journal / Neuroscience / Cannula Implantation into the Cisterna Magna of…
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Neuroscience

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JoVE Journal Neuroscience
Cannula Implantation into the Cisterna Magna of Rodents
 

Cannula Implantation into the Cisterna Magna of Rodents

Article DOI: 10.3791/57378-v • 10:13 min • May 23rd, 2018
May 23rd, 2018 •
1, 1, 1, 1, 1,2, 3, 3,4, 1,3
1Center for Translational Neuromedicine, Division of Glial Therapeutics, University of Copenhagen, 2Department of Anesthesiology, Yale School of Medicine, 3Center for Translational Neuromedicine, Division of Glial Therapeutics, University of Rochester Medical Center, 4Department of Experimental Medical Science, Wallenberg Center for Molecular Medicine, Lund University

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Summary
Automatic Translation

Here we describe a protocol to perform cisterna magna cannulation (CMc), a minimally invasive way to deliver tracers, substrates and signaling molecules into the cerebrospinal fluid (CSF). Combined with different imaging modalities, CMc enables glymphatic system and CSF dynamics assessment, as well as brain-wide delivery of various compounds.

Tags

Cannula Implantation Cisterna Magna Rodents Surgical Procedure Tracers Substrates Signaling Molecules Cerebrospinal Fluid (CSF) Neuroscience CSF-ISF Dynamics Brain Parenchyma Neurological Diseases CSF-ISF Fluxes Blood-brain Barrier Cannula Preparation Dental Needle PE-10 Tubing Artificial Cerebrospinal Fluid (aCSF) Anesthesia Stereotaxic Apparatus
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