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干细胞衍生的抗原特异性调节性T细胞对自身免疫的发展
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Immunologie und Infektion
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JoVE Journal Immunologie und Infektion
Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
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干细胞衍生的抗原特异性调节性T细胞对自身免疫的发展

8,490 Views

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10:10 min

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November 08, 2016

DOI:

10.3791/54720-v

DOI:
10.3791/54720-v

•

10:10 min
November 08, 2016

•

4 Views
, , ,
1Department of Microbiology and Immunology,The Pennsylvania State University College of Medicine

Summary

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We present here a method to develop functional antigen (Ag)-specific regulatory T cells (Tregs) from induced pluripotent stem cells (iPSCs) for immunotherapy of autoimmune arthritis in a murine model.

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Stem CellRegulatory T CellsAutoimmune ArthritisImmunotherapyAntigen-specificInduced Pluripotent Stem Cells (iPSCs)OP9 Feeder CellsFlt3-LigandIL-7

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Haque, M., Fino, K., Sandhu, P., Song, J. Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity. J. Vis. Exp. (117), e54720, doi:10.3791/54720 (2016).

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