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In Vitro Recording of Mesenteric Afferent Nerve Activity in Mouse Jejunal and Colonic Segments
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1Laboratory of Experimental Medicine and Pediatrics, Division of Gastroenterology,University of Antwerp, 2Visceral Pain Group, Discipline of Medicine,University of Adelaide, 3Department of Biomedical Sciences,University of Sheffield, 4Department of Pharmacy, Pharmacology and Postgraduate Medicine,University of Hertfordshire, 5Department of Gastroenterology and Hepatology,Antwerp University Hospital
Kapitel
- 00:05Titel
- 01:16Preparation of the Jejunal Afferent Nerve
- 05:58Afferent Nerve Recording
- 07:53Results: Schematic Representation of Different Afferent Fiber Units Based on Their Mechanosensitive Profile
- 09:13Conclusion
Mesenteric afferent nerves convey information from the gastrointestinal tract towards the brain regarding normal homeostasis as well as pathophysiology. Gastrointestinal afferent nerve activity can be assessed by mounting isolated intestinal segments with attached afferent nerves into an organ bath, isolating the nerve, and assessing basal as well as stimulated activity.
