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前駆細胞が媒介する肝細胞の再生を研究するためにゼブラフィッシュにおけるエタノール誘発性線維症肝臓モデルの開発
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Entwicklungsbiologie
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JoVE Journal Entwicklungsbiologie
Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration
Please note that all translations are automatically generated. Click here for the English version.

前駆細胞が媒介する肝細胞の再生を研究するためにゼブラフィッシュにおけるエタノール誘発性線維症肝臓モデルの開発

9,019 Views

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10:42 min

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May 13, 2016

DOI:

10.3791/54002-v

DOI:
10.3791/54002-v

•

10:42 min
May 13, 2016

•

1 Views
, ,
1School of Biology, Parker H. Petit Institute for Bioengineering and Bioscience,Georgia Institute of Technology

Summary

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Sustained fibrosis with deposition of excessive extracellular matrix proteins leads to cirrhosis. Alcohol abuse is one of the main causes of severe liver disease. We established an ethanol-induced zebrafish fibrotic liver model to study the mechanisms and strategies of promoting hepatocyte regeneration upon alcohol-induced injury.

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Huang, M., Xu, J., Shin, C. H. Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration. J. Vis. Exp. (111), e54002, doi:10.3791/54002 (2016).

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