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Um método para a atividade neural remotamente Silenciando em Roedores Durante fases distintas de Aprendizagem
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JoVE Journal Verhalten
A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning
DOI:

09:22 min

June 22, 2015

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Kapitel

  • 00:05Titel
  • 01:15Stereotaxic Surgery for Viral Infusion
  • 04:43Pharmacological Treatment (Administration of the Designer Drug) and Behavioral Procedure (Sensory Preconditioning)
  • 07:26Post Procedure Analyses
  • 07:54Results: Sensory Preconditioning in Silenced and Control Rats
  • 08:53Conclusion

Summary

Automatische Übersetzung

This protocol describes how to temporarily and remotely silence neuronal activity in discrete brain regions while rats are engaged in learning and memory tasks. The approach combines pharmacogenetics (Designer-Receptors-Exclusively-Activated-by-Designer-Drugs) with a behavioral paradigm (sensory preconditioning) that is designed to distinguish between different components of learning.

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