Ligadura del conducto biliar en los ratones: Inducción de la injuria hepática inflamatoria y fibrosis por colestasis obstructiva

Disruption of bile flow results in severe inflammatory cholestatic liver injury with a characteristic time-dependent sequence of morphological alterations. Here we present a protocol for the surgical ligation of the common bile duct in mice that allows to induce a strong fibrotic response after 21 to 28 days.