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Immunology and Infection

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JoVE Journal Immunology and Infection
Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
 

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat

Article DOI: 10.3791/52018-v • 08:28 min • October 29th, 2014
October 29th, 2014 •
1, 1, 1, 2, 1
1School of Pharmacy, University College London, 2Mucin Biology Group, University of Gothenburg

Kapitel

Summary
Automatic Translation

Here, a procedure is described for the establishment of systemic infection in the neonatal rat with cultures of Escherichia coli K1. This non-invasive procedure permits colonization of the gastrointestinal tract, translocation of the pathogen to the systemic circulation, and invasion of the central nervous system at the choroid plexus.

Tags

Non-invasive Model Neuropathogenic Escherichia Coli Infection Neonatal Rat Animal Host Bacterial Pathogen Infection Model Systemic Infection E. Coli K1 Gastrointestinal Tract Colonization Gut-lymph-blood-brain Course Of Infection Age Dependency E. Coli O18:K1 Enhanced Virulence Colonization Rate Translocation To Blood Compartment Invasion Of Meninges Choroid Plexus Transit Central Nervous System Penetration Local Inflammation Lethal Outcome Mechanism Of Pathogenesis Therapeutic Interventions Bacterial Virulence
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