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Neo-Islet Formation in Leber der diabetischen Mäuse von Helper-abhängigen Adenovirus-Vektor-vermittelten Gentransfer
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Medizin
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JoVE Journal Medizin
Neo-Islet Formation in Liver of Diabetic Mice by Helper-dependent Adenoviral Vector-Mediated Gene Transfer
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Neo-Islet Formation in Leber der diabetischen Mäuse von Helper-abhängigen Adenovirus-Vektor-vermittelten Gentransfer

11,489 Views

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16:59 min

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October 10, 2012

DOI:

10.3791/4321-v

DOI:
10.3791/4321-v

•

16:59 min
October 10, 2012

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2 Views
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1Department of Medicine,Baylor College of Medicine , 2Division of Diabetes, Endocrinology & Metabolism, Diabetes & Endocrinology Research Center,Baylor College of Medicine , 3Department of Molecular & Cellular Biology,Baylor College of Medicine

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Neo-Islet FormationLiverDiabetic MiceHelper-dependent Adenoviral Vector-Mediated Gene TransferType 1 DiabetesT Cell-mediated Autoimmune DestructionInsulin-producing CellsPancreasInsulin ReplacementIslet TransplantationDonor AvailabilityLong-term ImmunosuppressionInduced Islet NeogenesisGene TransferNeuogenin3 (Ngn3)Islet Lineage-defining Specific Transcription FactorBetacellulin (Btc)Islet Growth FactorAdenoviral Vectors (Ads)Gene Transfer VectorEarly Generation AdsSafety ProfileTransgene ExpressionChronic ToxicityViral Coding SequencesAd Cis ElementsVector Replication And PackagingProtocolHDAd-Ngn3HDAd-BtcSTZ-induced Diabetic Mice‘neo Islets’LiverHyperglycemia

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Li, R., Oka, K., Yechoor, V. Neo-Islet Formation in Liver of Diabetic Mice by Helper-dependent Adenoviral Vector-Mediated Gene Transfer. J. Vis. Exp. (68), e4321, doi:10.3791/4321 (2012).

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