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Kapitel
- 00:00Titel
- 01:28Overall Scheme of the Experiment
- 02:36Preparation of Pathogenic Antibody
- 04:06Injection of Collagen VII-specific IgG into Mice
- 06:47Clinical Evaluation of Disease Severity
- 09:13Analysis of Tissue-bound and Circulation Collagen-specific Antibodies
- 10:19Representative Results
- 11:41Conclusions
I djurmodellen som beskrivs i vårt nuvarande arbete, renade IgG-antikroppar mot en sträcka av 200 aminosyror (aa 757-967) av kollagen VII injiceras upprepade gånger i möss återger blåsbildning fenotypen samt histo-och immunopatologiska egenskaper karakteristiska för humant epidermolysis bullosa acquisita (EBA)<sup> 1</sup>.
Tags
Granulocyte-dependentAutoantibody-inducedSkin BlisteringAutoimmune PhenomenaSelf-toleranceAutoimmune ResponseWitebsky’s PostulatesDiagnosing Autoimmune DiseasePassive Transfer Of AutoantibodiesEpidermolysis Bullosa Acquisita (EBA)Experimental ModelsCollagen VIIBlistering PhenotypeHisto- And Immunopathological FeaturesHuman EBAWidespread DiseaseDose Of Administered Collagen VII-specific IgGGranulocyte Recruitment And ActivationInflammatory Pathway
