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Granulócitos-dependente Blistering pele induzida por auto-anticorpos
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Kapitel
- 00:00Titel
- 01:28Overall Scheme of the Experiment
- 02:36Preparation of Pathogenic Antibody
- 04:06Injection of Collagen VII-specific IgG into Mice
- 06:47Clinical Evaluation of Disease Severity
- 09:13Analysis of Tissue-bound and Circulation Collagen-specific Antibodies
- 10:19Representative Results
- 11:41Conclusions
No modelo animal descrito no nosso trabalho, purificou anticorpos IgG contra uma extensão de 200 aminoácidos (aa 757-967) de colagénio VII são injectados repetidamente em ratinhos que reproduzem o fenótipo empolar, bem como a histo-e imunopatológicas características de humano epidermólise bolhosa adquirida (EBA)<sup> 1</sup>.
Tags
Granulocyte-dependentAutoantibody-inducedSkin BlisteringAutoimmune PhenomenaSelf-toleranceAutoimmune ResponseWitebsky’s PostulatesDiagnosing Autoimmune DiseasePassive Transfer Of AutoantibodiesEpidermolysis Bullosa Acquisita (EBA)Experimental ModelsCollagen VIIBlistering PhenotypeHisto- And Immunopathological FeaturesHuman EBAWidespread DiseaseDose Of Administered Collagen VII-specific IgGGranulocyte Recruitment And ActivationInflammatory Pathway
