Chapter 10
Gene Expression
![Cell-Specific Gene Expression](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11605.jpg)
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same…
![Regulation of Expression Occurs at Multiple Steps](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11606.jpg)
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves…
![Cooperative Binding of Transcription Regulators](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11608.jpg)
Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences…
![Prokaryotic Transcriptional Activators and Repressors](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11609.jpg)
The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the…
![The Eukaryotic Promoter Region](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11611.jpg)
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start…
![Co-activators and Co-repressors](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11612.jpg)
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in…
![Eukaryotic Transcription Inhibitors](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11614.jpg)
Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding…
![Combinatorial Gene Control](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11615.jpg)
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of…
![Master Transcription Regulators](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11617.jpg)
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often…
![Epigenetic Regulation](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/10803.jpg)
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases…
![Identifying Transcription Factor Olig2 Genomic Binding Sites in Acutely Purified PDGFRα+ Cells by Low-cell Chromatin Immunoprecipitation Sequencing Analysis](https://jovecdn2.ccindex.cn/files/thumbs/57547_t.png)
In mammalian cells, gene transcription is regulated in a cell type specific manner by the interactions of transcriptional factors with genomic DNA.…
![A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure](https://jovecdn2.ccindex.cn/files/thumbs/58617_t.png)
A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
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As genomes of a wider variety of animals become available, there is an increasing need for tools that can capture dynamic epigenetic changes in these…